PTPRO
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Official Full Name
protein tyrosine phosphatase, receptor type, O -
Overview
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. -
Synonyms
PTPRO;protein tyrosine phosphatase, receptor type, O;receptor-type tyrosine-protein phosphatase O;GLEPP1;NPHS6;osteoclastic transmembrane protein tyrosine phosphatase;PTP oc;PTP U2;PTPU2;GLEPP 1;Glomerular epithelial protein 1;Phosphotyrosine phosphatase U2;Protein tyrosine phosphatase PTP U2;Protein tyrosine phosphatase PTPU2;Protein tyrosine phosphatase receptor type O;Protein tyrosine phosphatase U2;PTP-U2;PTPase U2;PTPRO_HUMAN;PTPROt;PTPU 2;R-PTP-O;Receptor type protein tyrosine phosphatase O;Receptor type tyrosine protein phosphatase O;PTP phi;protein tyrosine phosphatase PTP-U2;osteoclastic transmembrane protein-tyrosine phosphatase;PTP-OC
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Chicken
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PTPRO-13704M | Recombinant Mouse PTPRO Protein | Mammalian Cells | Mouse | His |
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| PTPRO-28582TH | Recombinant Human PTPRO | Wheat Germ | Human | Non | 180 amino acids |
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| PTPRO-28853TH | Recombinant Human PTPRO | Wheat Germ | Human | Non | 598 amino acids |
|
| PTPRO-5438Z | Recombinant Zebrafish PTPRO | Mammalian Cells | Zebrafish | His |
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| PTPRO-5698C | Recombinant Chicken PTPRO | Mammalian Cells | Chicken | His |
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| Ptpro-6812M | Recombinant Mouse Ptpro protein, His & T7-tagged | E.coli | Mouse | His&T7 | Phe948~Met1205 |
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| PTPRO-2672HCL | Recombinant Human PTPRO 293 Cell Lysate | HEK293 | Human | Non |
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| PTPRO-2673HCL | Recombinant Human PTPRO 293 Cell Lysate | HEK293 | Human | Non |
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| PTPRO-2674HCL | Recombinant Human PTPRO 293 Cell Lysate | HEK293 | Human | Non |
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| PTPRO-2643H | Recombinant Human PTPRO Protein, His-tagged | E.coli | Human | His | Phe938-Met1195 |
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| PTPRO-418HF | Recombinant Full Length Human PTPRO Protein | In Vitro Cell Free System | Human | Full L. 598 amino acids |
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| Ptpro-5250M | Recombinant Mouse Ptpro Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| PTPRO-6716H | Recombinant Human PTPRO Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| PTPRO-6718H | Recombinant Human PTPRO Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| PTPRO-7289M | Recombinant Mouse PTPRO Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PTPRO-7289M-B | Recombinant Mouse PTPRO Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PTPRO involved in several pathways and played different roles in them. We selected most pathways PTPRO participated on our site, such as Signaling events mediated by Stem cell factor receptor (c-Kit), which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling events mediated by Stem cell factor receptor (c-Kit) | STAP1,EVLA,MAP4K1,SH2B3 |
Protein Function
PTPRO has several biochemical functions, for example, Wnt-protein binding,phosphatase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRO itself. We selected most functions PTPRO had, and list some proteins which have the same functions with PTPRO. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Wnt-protein binding | SFRP4,PORCN,FZD8A,Fzd4,FZD1,SZL,FZD7,FZD2,APCDD1,FZD3A |
| transmembrane receptor protein tyrosine phosphatase activity | PTPRD,PTPRR,PTPRN2,PTPRM,PTPRUB,PTPRF,PTPRC,PTPRB,PTPRE,PTPN6 |
| protein binding | HIST1H3F,TSPAN15,PIKFYVE,UBE2D2A,ERCC6L,LTF,SLC25A46,NFKBID,CASP8,TUBB2A |
| protein homodimerization activity | ECE1,HNF1B,PLCB1,S100A10,DEM1,CD8A,EFR3A,RBM11,RRAGA,GGCT |
| phosphatase activity | DUSP13A,PHOSPHO1,DUSP19A,TIGARB,PTPRFB,CDC14AB,PTENA,ATP1A1,CTDNEP1A,PTPRQ |
| protein tyrosine phosphatase activity | DUSP6,MTMR6,CDC14AA,KIAA1274,PTPRZ1,MTMR14,DUSP22,MTMR7A,MTMR3,PTPN9 |
Interacting Protein
PTPRO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRO here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRO.
PDPK1;ERBB2;NTRK1;INSR;LCK;MET;PDGFRB;CDH2;EPOR;CBL;MAPK3;CTNNB1;CSK;TEC;WAS;NSF;PXN;TEK
Resources
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References
- Liu, Z; Hou, JJ; et al. Protein tyrosine phosphatase receptor type O expression in the tumor niche correlates with reduced tumor growth, angiogenesis, circulating tumor cells and metastasis of breast cancer. ONCOLOGY REPORTS 33:1908-1914(2015).
- Jiang, RQ; Chen, DY; et al. Survival and Inflammation Promotion Effect of PTPRO in Fulminant Hepatitis Is Associated with NF-kappa B Activation. JOURNAL OF IMMUNOLOGY 193:5161-5170(2014).
