PTPN4
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Official Full Name
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -
Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008] -
Synonyms
PTPN4;protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte);MEG;PTPMEG;PTPMEG1;tyrosine-protein phosphatase non-receptor type 4;PTPase-MEG1;megakaryocyte phosphatase;protein tyrosine phosphatase MEG1;protein-tyrosine phosphatase MEG1;megakaryocyte protein-tyrosine phosphatase
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PTPN4-3707R | Recombinant Rhesus monkey PTPN4 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| PTPN4-603H | Recombinant Human PTPN4, GST-tagged | E.coli | Human | GST | 637-926 a.a. |
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| PTPN4-2005H | Recombinant Human PTPN4 Protein, His&GST-tagged | E.coli | Human | His&GST | Asn616-Lys926 |
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| PTPN4-3524R | Recombinant Rhesus Macaque PTPN4 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PTPN4-3524R-B | Recombinant Rhesus Macaque PTPN4 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| PTPN4-683H | Recombinant Human PTPN4 protein, GST-tagged | E.coli | Human | GST | 604-927 aa |
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Involved Pathway
PTPN4 involved in several pathways and played different roles in them. We selected most pathways PTPN4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PTPN4 has several biochemical functions, for example, cytoskeletal protein binding,non-membrane spanning protein tyrosine phosphatase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN4 itself. We selected most functions PTPN4 had, and list some proteins which have the same functions with PTPN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| non-membrane spanning protein tyrosine phosphatase activity | DUSP1,PTPN9,PTPN11,PTPN18,ACP1,PTPN12 |
| protein binding | GTF3C5,LRP2BP,RAD51L3,TMCO6,MAFB,HIPK1,CCDC28A,ERC2,UBE3A,CCNL2 |
| cytoskeletal protein binding | NF2A,EPB41L3A,ALDOB,EPB41L5,LIN7C,CAPN10,PACSIN1,B4GALT1,PKD2,EPB41L4B |
Interacting Protein
PTPN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN4.
CRK;KAT5;MAPK12;ABL1;FYN;NCK1;PIK3R1;GRB2;ZZEF1;TK1;LPL;EEF1G;ATRX;EEF1A1
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