PTPN3
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Official Full Name
protein tyrosine phosphatase, non-receptor type 3 -
Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PTPN3;protein tyrosine phosphatase, non-receptor type 3;tyrosine-protein phosphatase non-receptor type 3;PTPH1;protein-tyrosine phosphatase H1;cytoskeletal-associated protein tyrosine phosphatase;PTP-H1;DKFZp686N0569
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- His&T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PTPN3-3954H | Recombinant Human PTPN3 protein, His-tagged | E.coli | Human | His | 308-508 aa | |
| PTPN3-13685M | Recombinant Mouse PTPN3 Protein | Mammalian Cells | Mouse | His |
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| PTPN3-8090H | Recombinant Human PTPN3 protein, His & T7-tagged | E.coli | Human | His&T7 | Ser18~Leu259 |
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| Ptpn3-8091M | Recombinant Mouse Ptpn3 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Glu704~Leu906 |
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| PTPN3-2683HCL | Recombinant Human PTPN3 293 Cell Lysate | HEK293 | Human | Non |
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| PTPN3-7281M | Recombinant Mouse PTPN3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PTPN3-7281M-B | Recombinant Mouse PTPN3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PTPN3 involved in several pathways and played different roles in them. We selected most pathways PTPN3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PTPN3 has several biochemical functions, for example, ATPase binding,cytoskeletal protein binding,phosphotyrosine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN3 itself. We selected most functions PTPN3 had, and list some proteins which have the same functions with PTPN3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine phosphatase activity | PTPN4B,EVLA,MTMR7,DUSP4,LRP8,DUSP16,PTPN23A,DUSP8A,KIAA1274,SSH2 |
| sodium channel regulator activity | SCN2B,FXYD7,YWHAH,GPD1L,PRSS30,NOS1,FXYD5,AGT,FXYD6,TMPRSS3 |
| cytoskeletal protein binding | NEBL,ANXA2,ANXA2A,PDLIM3,ALDOC,DES,FABP3,LDB3,PACSIN2,DYNLL2 |
| phosphotyrosine binding | CBLB,ZAP70,FGR,MAPK3,GRB2,CBL,MAPK1,CBLC,SHC1,STAP1 |
| ATPase binding | FXYD1,ATP6V0A4,DERL1,PIH1D1,ATP6V0A1A,DNAJC10,SNTA1,CHMP4A,DRD1A,METTL21A |
| protein binding | OLIG1,PHC3,WBSCR27,INPP5K,FOXP3,ACAT2,FAM107A,ITGB4,PGM1,SYT6 |
Interacting Protein
PTPN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN3.
GHR;YWHAG;LMO1;YWHAB;AKR1C1;DIP2A;ZCCHC10
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