PTP4A3
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Official Full Name
protein tyrosine phosphatase type IVA, member 3 -
Overview
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] -
Synonyms
PTP4A3;protein tyrosine phosphatase type IVA, member 3;PRL3;PRL-3;PRL-R;protein tyrosine phosphatase type IVA 3;protein-tyrosine phosphatase 4a3;potentially prenylated protein tyrosine phosphatase;protein-tyrosine phosphatase of regenerating liver 3
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- E.coli
- N-His
- Mammalian Cells
- HEK293
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
PTP4A3 involved in several pathways and played different roles in them. We selected most pathways PTP4A3 participated on our site, such as Signaling events mediated by PRL, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTP4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling events mediated by PRL | PTP4A1,ATF5,LRP8,PTP4A2,RABGGTB,RABGGTA |
Protein Function
PTP4A3 has several biochemical functions, for example, prenylated protein tyrosine phosphatase activity,protein tyrosine/serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTP4A3 itself. We selected most functions PTP4A3 had, and list some proteins which have the same functions with PTP4A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| prenylated protein tyrosine phosphatase activity | PTP4A2 |
| protein tyrosine/serine/threonine phosphatase activity | RNGTT,DUSP19B,DUSP3,SACM1LB,PTPMT1,MTMR2,EYA3,DUSP15,TPTE,PTP4A2B |
Interacting Protein
PTP4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTP4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTP4A3.
Tcr-alpha;q65zq1_human;MYO1C;TNPO2;TIMM23;SURF4;TTI1;PSMD3;ZW10;MYO1B;OPA1;DPM1;USO1
Resources
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References
- Sharlow, ER; Wipf, P; et al. Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents. EXPERT OPINION ON INVESTIGATIONAL DRUGS 23:661-673(2014).
- Guzinska-Ustymowicz, K; Kisluk, J; et al. Expression of phosphatase of regenerating liver-3 (PRL-3) in endometrioid cancer and lymph nodes metastases. ADVANCES IN MEDICAL SCIENCES 58:221-226(2013).
