PTK6
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Official Full Name
PTK6 PTK6 protein tyrosine kinase 6 -
Overview
The expression of protein-tyrosine-kinase 6 (PTK6, BRK-breast cancer related kinase) is restricted to normal differentiating epithelial cells. PTK6/BRK is overexpressed in many breast and ovarian cancer cell lines and the expression level is associated with poor prognosis. -
Synonyms
PTK6;PTK6 protein tyrosine kinase 6;protein-tyrosine kinase 6;BRK;breast tumor kinase;protein-tyrosine kinase BRK;tyrosine-protein kinase BRK;FLJ42088
Recombinant Proteins
- Human
- Mouse
- Insect Cells
- Mammalian cells
- E.coli
- Insect Cell
- Sf9 Insect Cell
- HEK293
- HEK293T
- Insect (sf21)
- GST
- Flag
- His&T7
- His
- Non
- His&GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PTK6 involved in several pathways and played different roles in them. We selected most pathways PTK6 participated on our site, such as EGFR1 Signaling Pathway,Focal Adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | LAMC3,BIRC2,CDC42L2,COL6A4,COL1A1,MAPK9,VEGFAA,TNK1,THBS3,ITGA9 |
| EGFR1 Signaling Pathway | GRB10,REPS1,CEBPA,ZPR1,PTPN12,RALBB,RALBP1,ABI1B,EPPK1,MTA2 |
Protein Function
PTK6 has several biochemical functions, for example, ATP binding,identical protein binding,non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTK6 itself. We selected most functions PTK6 had, and list some proteins which have the same functions with PTK6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | HAO1,RCHY1,GSTM2,PLA2G1B,MAP7,SLC27A2,LPL,AMACR,PLG,FGF18B |
| identical protein binding | LRRK2,PCBD1,HSP90AA1,SMG9,SEPHS1,HCN4,PDGFB,PPP1R13L,TPD52L1,STAC3 |
| non-membrane spanning protein tyrosine kinase activity | FYNB,TYK2,RIPK2,STYK1,CLK1,SRC,EIF2AK2,LYN,BAZ1B,JAK1 |
| protein binding | FOXRED2,RPS11,HENMT1,SNX2,OTULIN,USP14,ZFP488,ST13,ZNF695,AGT |
| ATP binding | UBE2T,ATAD5,MAPK12,FGR,PRPF4B,MARK3,MELK,PANK1A,TTK,WEE2 |
Interacting Protein
PTK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTK6.
SFPQ;80125;WASL;FCHO1;REL;EFHC2
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References
- Ludyga, N; Anastasov, N; et al. Effects of Simultaneous Knockdown of HER2 and PTK6 on Malignancy and Tumor Progression in Human Breast Cancer Cells. MOLECULAR CANCER RESEARCH 11:381-392(2013).
- Li, X; Lu, Y; et al. Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. ONCOGENE 31:4372-4383(2012).
