PTGR2
-
Official Full Name
prostaglandin reductase 2 -
Overview
This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. -
Synonyms
PTGR2;prostaglandin reductase 2;ZADH1, zinc binding alcohol dehydrogenase domain containing 1;FLJ39091;15 oxoprostaglandin 13 reductase;15 oxoprostaglandin delta 13 reductase;DKFZp686P10120;FLJ99229;PGR 2;PGR2;PTGR 2;Zinc binding alcohol dehydrogenase domain containing 1;Zinc binding alcohol dehydrogenase domain containing protein 1;PRG-2;15-oxoprostaglandin 13-reductase;15-oxoprostaglandin-delta13-reductase;zinc binding alcohol dehydrogenase, domain containing 1;zinc-binding alcohol dehydrogenase domain-containing protein 1;ZADH1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PTGR2 involved in several pathways and played different roles in them. We selected most pathways PTGR2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PTGR2 has several biochemical functions, for example, 13-prostaglandin reductase activity,15-oxoprostaglandin 13-oxidase activity,NOT zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGR2 itself. We selected most functions PTGR2 had, and list some proteins which have the same functions with PTGR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 15-oxoprostaglandin 13-oxidase activity | PTGR1 |
| 13-prostaglandin reductase activity | PTGR1 |
Interacting Protein
PTGR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGR2.
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References
- Zhao, RJ; Pan, ZY; et al. Stimulation of non-neuronal muscarinic receptors enhances chemerin/ChemR23 system in dysfunctional endothelial cells. LIFE SCIENCES 92:10-16(2013).
- Naidansuren, P; Park, CW; et al. Molecular characterization of bovine placental and ovarian 20 alpha-hydroxysteroid dehydrogenase. REPRODUCTION 142:723-731(2011).
