PTGER1
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Official Full Name
prostaglandin E receptor 1 (subtype EP1), 42kDa -
Overview
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptors activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. -
Synonyms
PTGER1;prostaglandin E receptor 1 (subtype EP1), 42kDa;prostaglandin E receptor 1 (subtype EP1), 42kD;prostaglandin E2 receptor EP1 subtype;EP1;PGE receptor EP1 subtype;PGE2 receptor EP1 subtype;Prostaglandin E receptor 1 subtype EP1 42kDa;Prostaglandin E receptor 1 subtype EP1;Prostanoid EP1 receptor;PGE receptor, EP1 subtype;prostaglandin E receptor 1, subtype EP1
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mus musculus
- Dog
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- His&Fc&Avi
Involved Pathway
PTGER1 involved in several pathways and played different roles in them. We selected most pathways PTGER1 participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGER1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | GRM6,FPR1,APLNRB,GRIA3B,GABRD,GHSRA,TAAR12I,ADORA3,GRIN2D,GLRA1 |
| Calcium signaling pathway | TNNC1B,CHRM5B,PHKG1A,CAMK2A,ATP2A2B,PRKCBA,GNAS,PTGER1B,ADRa1A,CAMK2B |
| Pathways in cancer | Flt3l,RET,VEGFB,FLT3,CBL,MSH2,FOS,NRAS,FGF2,RUNX1 |
Protein Function
PTGER1 has several biochemical functions, for example, prostaglandin E receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGER1 itself. We selected most functions PTGER1 had, and list some proteins which have the same functions with PTGER1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| prostaglandin E receptor activity | PTGER1A,PTGER2A,PTGER1B,PTGER4B,HPGD,PTGER3,PTGER4A,PTGER4,PTGER4C,PTGER1C |
Interacting Protein
PTGER1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGER1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGER1.
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