PTAFR
-
Official Full Name
Platelet-Activating Factor Receptor -
Overview
PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling. Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain. In leukocyte cell populations the receptor is found on platelets, myocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor. Human monocytes treated with INF-γ have a 2-6 fold increase in PAF receptor expression compared to untreated cells. -
Synonyms
PTAFR;platelet-activating factor receptor;PAFR;PAF-R;OTTHUMP00000004040;OTTHUMP00000004041;PAF Receptor
Recombinant Proteins
- Mouse
- Rat
- Human
- Mus musculus
- Sus scrofa (Pig)
- Goat
- Bovine
- Macaca mulatta
- Guinea pig
- Mammalian Cell
- HEK293
- Wheat Germ
- E.coli expression system
- His
- Non
- His&Flag
- His&Fc&Avi
Involved Pathway
PTAFR involved in several pathways and played different roles in them. We selected most pathways PTAFR participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTAFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Staphylococcus aureus infection | HLA-DRB1,CFB,ITGB2L,MBL2,HLA-DQA1,FPR1,CFH,FGG,C3AR1,C4A |
| Calcium signaling pathway | PLN,TNNC1A,GNA15,PRKACAB,HTR2B,MYLK,CACNA1BA,ATP2B2,NOS1,PLCD3A |
| Neuroactive ligand-receptor interaction | CRHR2,GLRA3,PTGER3,OPRD1B,PTH2R,P2RX6,GRM1,APLNR,THRAA,CHRNA6 |
Protein Function
PTAFR has several biochemical functions, for example, G-protein coupled purinergic nucleotide receptor activity,G-protein coupled receptor activity,lipopolysaccharide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTAFR itself. We selected most functions PTAFR had, and list some proteins which have the same functions with PTAFR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled purinergic nucleotide receptor activity | P2RY14,P2RY1,P2RY6,P2RY8,GPR34B,P2RY13,P2RY4,P2RY2,P2RY11,P2RY10 |
| platelet activating factor receptor activity | PDGFRL,PDGFRB |
| lipopolysaccharide receptor activity | TLR2,LY96,TLR4,SCARB1 |
| phospholipid binding | PICALMA,APOH,VAMP2,PAFAH2,APOC3,GOT2,NUP35,APOEB,BPIFC,ARHGAP44 |
| lipopolysaccharide binding | HSPD1,TLR2,SELP,TRIL,SPON2,CD6,CD14,TLR4,P2RX7,CATHL3 |
| G-protein coupled receptor activity | OLFR497,MAS1,TAAR1,GPR34L,TAS2R116,GPR126,TAAR14I,BAI3,PTGER1A,LPAR4 |
Interacting Protein
PTAFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTAFR here. Most of them are supplied by our site. Hope this information will be useful for your research of PTAFR.
CALM1;GORAB;SPATA24;GTPBP3
Resources
Research Area
Bioactive Lipid G Protein-Coupled ReceptorsNegative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
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References
- Leoni, G; Gripentrog, J; et al. Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response. JOURNAL OF LEUKOCYTE BIOLOGY 97:87-101(2015).
- Yu, Y; Zhang, MX; et al. Transactivation of epidermal growth factor receptor through platelet- activating factor/receptor in ovarian cancer cells. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 33:-(2014).
