PSMD5
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Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -
Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator base. -
Synonyms
PSMD5;proteasome (prosome, macropain) 26S subunit, non-ATPase, 5;26S proteasome non-ATPase regulatory subunit 5;KIAA0072;S5B;26S proteasome subunit S5B;26S protease subunit S5 basic;MGC23145
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Cynomolgus
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PSMD5 involved in several pathways and played different roles in them. We selected most pathways PSMD5 participated on our site, such as APC/C-mediated degradation of cell cycle proteins,APC/C:Cdc20 mediated degradation of Securin,APC/C:Cdc20 mediated degradation of mitotic proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | PSMA8,PSMD10,NEK2,UBE2C,PSME3,ANAPC10,PSMD14,PSMD9 |
| ARMS-mediated activation | KLB,SLC14A2,JAK3,PTPRA,DUSP9,FRS2A,RASGEF1A,EGFR,HBEGF,PSMD9 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | PSME3,PSMD10,ANAPC10,PSMD9,PSMA8,UBE2C,PSMD14,NEK2 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | PSMD14,PSMD9,PSMD10,PSMA8,AURKB,PSME3,ANAPC10,UBE2C |
| APC/C-mediated degradation of cell cycle proteins | NEK2,PSMD14,CDK2,ANAPC10,AURKB,PSMD10,PSME3,PSMA8,PSMD9,UBE2C |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | PSMD10,UBE2C,PSMD9,PSMD14,ANAPC10,PSME3,NEK2,PSMA8 |
| APC/C:Cdc20 mediated degradation of Securin | UBE2C,PSMD9,PSMD10,PSMD14,ANAPC10,PSMA8,PSME3 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | HNRNPD,PSME3,PSMD14,EIF4G1,PSMA8,PSMD9,PSMD10 |
Protein Function
PSMD5 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMD5 itself. We selected most functions PSMD5 had, and list some proteins which have the same functions with PSMD5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RPGR,NOTCH2,STAG3,GLYR1,NUPL1,ABCE1,MED21,FOXG1,YTHDC1,MOCS3 |
Interacting Protein
PSMD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMD5.
PSMC2;PSMC1;TFCP2
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