PSMD10
-
Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -
Overview
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20. -
Synonyms
PSMD10;proteasome (prosome, macropain) 26S subunit, non-ATPase, 10;26S proteasome non-ATPase regulatory subunit 10;gankyrin;p28;ankyrin repeat protein;26S proteasome regulatory subunit p28;hepatocellular carcinoma-associated protein p28-II;p28(GAN
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&T7
- His&SUMO
- His&Fc&Avi
Involved Pathway
PSMD10 involved in several pathways and played different roles in them. We selected most pathways PSMD10 participated on our site, such as APC/C-mediated degradation of cell cycle proteins,APC/C:Cdc20 mediated degradation of Securin,APC/C:Cdc20 mediated degradation of mitotic proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMD10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ARMS-mediated activation | SPRED1,HBEGF,SPTB,KLB,JAK2,PSME3,NEFLB,FRS2,CSF2RB,DUSP4 |
| APC/C-mediated degradation of cell cycle proteins | PSME3,NEK2,CDK2,PSMD9,PSMD5,PSMA8,ANAPC10,AURKB,PSMD14,UBE2C |
| APC/C:Cdc20 mediated degradation of mitotic proteins | PSMA8,PSMD5,UBE2C,ANAPC10,PSME3,NEK2,PSMD9,PSMD14 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | PSMD14,PSMD5,PSME3,UBE2C,ANAPC10,PSMD9,AURKB,PSMA8 |
| APC/C:Cdc20 mediated degradation of Securin | UBE2C,PSMD14,PSMD5,ANAPC10,PSMA8,PSME3,PSMD9 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | ANAPC10,PSMD14,NEK2,PSME3,PSMD5,PSMA8,UBE2C,PSMD9 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | PSMD9,PSMD14,PSME3,PSMA8,EIF4G1,HNRNPD,PSMD5 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | PSMD14,PSMD9,PSMD5,ANAPC10,UBE2C,PSMA8,PSME3,NEK2 |
Protein Function
PSMD10 has several biochemical functions, for example, protein binding,transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMD10 itself. We selected most functions PSMD10 had, and list some proteins which have the same functions with PSMD10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | PER1,IRF4,CHCHD2,TRIB2,TWIST1,PURA,EPN1,TP73,PPP1R13BB,PARK7 |
| protein binding | WHSC1L1,HOMEZ,CD9,UTP23,PTK7,NEU4,SPTA1,NKX3-1,CARF,DOK6 |
Interacting Protein
PSMD10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMD10 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMD10.
PSMC4;PSMC1;PSMD7
Resources
Related Services
Related Products
References
