PSMC4
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Official Full Name
proteasome (prosome, macropain) 26S subunit, ATPase, 4 -
Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified. -
Synonyms
PSMC4;proteasome (prosome, macropain) 26S subunit, ATPase, 4;MIP224;26S protease regulatory subunit 6B;MB67 interacting protein;MGC8570;MGC13687;MGC23214;protease 26S subunit 6;S6;Tat binding protein 7;TBP 7;TBP7;TBP-7;Tat-binding protein 7
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- Cynomolgus
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PSMC4 involved in several pathways and played different roles in them. We selected most pathways PSMC4 participated on our site, such as Proteasome,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMD4A,PSMC1B,PSMB2,IFNG,POMP,PSMA6A,PSMA6B,PSMF1,PSMC2,PSMB9A |
| Epstein-Barr virus infection | PTMA,IFNG,TRP53,AKT1,HDAC1,TRAF1,VIM,IRF3,PRKACG,HLA-DQA2 |
Protein Function
PSMC4 has several biochemical functions, for example, ATP binding,ATPase activity,TBP-class protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMC4 itself. We selected most functions PSMC4 had, and list some proteins which have the same functions with PSMC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PMS2,EVC2,EPHA4,ABCG1,NAPRT1,SPAG5,AIP,CTLA4,PKP2,LTBP2 |
| proteasome-activating ATPase activity | PSMC3,PSMC1,PSMC5,PSMC2,PSMC1B,PSMC6,PSMC1A |
| ATPase activity | INO80,KIF6,SMARCA5,ABCA5,EIF4A2,DYNC2H1,RNF213,ABCA6,VPS4B,KIF2C |
| TBP-class protein binding | HHEX,TAF1B,PSMC3,CAND2,GTF2A2,PSMC1A,PSMC1,THRA,DR1,PSMC5 |
| ATP binding | CCT7,GRK1,ATP1A3,DYRK4,ACTB1,GRK4,NETO2,SGK2,MYO1EB,SMARCA2 |
Interacting Protein
PSMC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMC4.
PSMD10;PSMC5
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