PSMC1
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Official Full Name
proteasome (prosome, macropain) 26S subunit, ATPase, 1 -
Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. -
Synonyms
PSMC1;proteasome (prosome, macropain) 26S subunit, ATPase, 1;26S protease regulatory subunit 4;p56;S4;proteasome 26S ATPase subunit 1;proteasome 26S subunit ATPase 1;proteasome 26S subunit, ATPase, 1;26S proteasome AAA-ATPase subunit RPT2;P26S4
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PSMC1 involved in several pathways and played different roles in them. We selected most pathways PSMC1 participated on our site, such as Proteasome,Epstein-Barr virus infection,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMB6,PSMD7,PSME4B,PSMD13,SHFM1,PSMC3,PSMB9A,IFNG1-2,PSMC6,PSMA6A |
| Viral carcinogenesis | SCRIB,CCND2,REL,PIK3CG,STAT5A,HIST1H2BJ,HIST1H4I,SRF,RANBP1,HLA-C |
| Epstein-Barr virus infection | RIPK1,POLR2G,CD19,PIK3R3,TNFAIP3,MAPK12,POLR2C,HSPA6,POLR3E,SPN |
Protein Function
PSMC1 has several biochemical functions, for example, ATP binding,ATPase activity,TBP-class protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMC1 itself. We selected most functions PSMC1 had, and list some proteins which have the same functions with PSMC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| proteasome-activating ATPase activity | PSMC1A,PSMC6,PSMC3,PSMC5,PSMC4,PSMC1B,PSMC2 |
| ATP binding | DNAJA4,HSPA4B,ITM2C,PFKL,BRAF,PGK1,PTK7,ZRANB3,MINK1,KIF23 |
| TBP-class protein binding | BRF1,BRF1A,HHEX,CAND1,DR1,THRA,EFCAB11,GTF2A2,TAF1B,PSMC3 |
| ATPase activity | RNF213,VWA8,KIF23,PEX6,ATAD2,KIF14,ABCA4,MLH3,EIF4A2,HSPA1B |
| protein binding | CD86,RPGRIP1,PRPF6,IL1R1,STON2,LGALS13,ITPKB,ATP7B,AKTIP,DNAJB1 |
| poly(A) RNA binding | STAU1,HIST1H4C,MRPS7,MADD,FBL,UBAP2L,CPSF4,ADARB1,DHX36,SNRNP40 |
Interacting Protein
PSMC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMC1.
PSMD2;PSMD5;PSMC2
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