PRR5
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Official Full Name
proline rich 5 (renal) -
Overview
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010] -
Synonyms
PRR5;proline rich 5 (renal);PP610;PROTOR1;PROTOR-1;FLJ20185k;proline-rich protein 5;protein observed with Rictor-1;Rho GTPase activating protein 8
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293T
- HEK293
- His
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PRR5 involved in several pathways and played different roles in them. We selected most pathways PRR5 participated on our site, such as TOR signaling,mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mTOR signaling pathway | VEGFAB,MAPK3,AKT2,RPS6KB2,EIF4E1C,STK11,INS1,TNF,BRAF,PRKCBA |
| TOR signaling | DDIT4L |
Protein Function
PRR5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PRR5 itself. We selected most functions PRR5 had, and list some proteins which have the same functions with PRR5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
PRR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRR5.
RICTOR;MTOR;RPS9;MAPKAP1;MLST8
Resources
Research Area
Phospholipases, Small GTPases, and Other Molecules in the Akt PathwaymTOR Complexes
PI3K Pathway
Related Services
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References
