PRPS2
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Official Full Name
phosphoribosyl pyrophosphate synthetase 2 -
Overview
This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. -
Synonyms
PRPS2;phosphoribosyl pyrophosphate synthetase 2;ribose-phosphate pyrophosphokinase 2;PRS II;ribose phosphate diphosphokinase 2;EC 2.7.6.1;Phosphoribosyl pyrophosphate synthetase II;PPRibP;Ribose phosphate pyrophosphokinase II;PRS-II;PPRibP synthetase;OTTHUMP00000022921;OTTHUMP00000214964;OTTHUMP00000214965;ribose-phosphate diphosphokinase 2;phosphoribosyl pyrophosphate synthase II;PRSII
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PRPS2 involved in several pathways and played different roles in them. We selected most pathways PRPS2 participated on our site, such as Pentose phosphate pathway,Purine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | PRIM2,PAPSS2B,RRM1,ENTPD4,PDE3B,PNPT1,AK8,POLR1B,PAICS,POLR2H |
| Biosynthesis of amino acids | PCXB,SDSL,ALDOC,ALDOB,MAT2AB,ALDOAA,GPT2,BCAT2,ASL,TALDO1 |
| Metabolic pathways | C1GALT1,UGT1A4,HSD11B1,PRPS1L1,PIK3C2B,LDHB,AK1,NDST2,OXSM,ASS1 |
| Carbon metabolism | ACADM,ALDOCA,GPR19,DLD,AGXT,IDH3B,GOT1,PRPS1,GOT2B,IDH1 |
| Pentose phosphate pathway | G6PDX,GPI,PRPS1B,RGN,GPI1,PFKMB,PFKP,PFKMA,PFKM,ALDOCB |
Protein Function
PRPS2 has several biochemical functions, for example, ADP binding,AMP binding,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPS2 itself. We selected most functions PRPS2 had, and list some proteins which have the same functions with PRPS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ribose phosphate diphosphokinase activity | PRPS1B,PRPS1A,PRPS1,PRPSAP1,PRPS1L1 |
| identical protein binding | TRIM21,LZTFL1,NFKBIA,CD74,MRI1,HAPLN2,KHDC1A,AMELX,HJURP,POLG2 |
| protein homodimerization activity | CEBPE,Il6ra,ASNSD1,ACTN3,MCL1B,GHR,TYMS,SYT6,GABRR1,SDCBP2 |
| ATP binding | SUPV3L1,KALRN,KIFC1,UBE2IA,UBE2NA,SMARCA4A,ROCK1,DYRK1AA,HSPH1,ABCD1 |
| AMP binding | PRKAG1,PRPS1,PYGM,PRKAG2,ACSS2,ACSS1,CYB5R3,APRT,FBP1,PYGL |
| GDP binding | PCK1,RAB14,PRPS1,GEM,RAB22A,RAB7,SRP54A,RAB10,RAB8A,RAN |
| carbohydrate binding | KLRC4-KLRK1,FCN1,POC1BL,GALNT3,Pla2r1,CALR3,CLEC2D,GANAB,CLEC4E,GALNT18A |
| protein binding | RTN4RL1,TBX2A,KLHL18,APLF,APOOL,HIP1,FAM114A1,FGF19,GAS1,TMEM119 |
| kinase activity | PRKCDA,NADKD1,PRKD3,NME2B.1,HYKK.2,TSSK5,TPK1,ALPK2,PRKACAA,STK30 |
Interacting Protein
PRPS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPS2.
PRPS1;PRPSAP1;NOTCH2NL;WDYHV1
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References
- Cunningham, JT; Moreno, MV; et al. Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer. CELL 157:1088-1103(2014).
- Fridman, A; Saha, A; et al. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. BIOCHEMICAL JOURNAL 454:91-99(2013).
