PRPF4
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Official Full Name
PRP4 pre-mRNA processing factor 4 homolog -
Overview
The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PRPF4;PRP4 pre-mRNA processing factor 4 homolog (yeast);U4/U6 small nuclear ribonucleoprotein Prp4;HPRP4;HPRP4P;PRP4;PRP4/STK/WD splicing factor;Prp4p;PRP4 homolog;WD splicing factor Prp4;U4/U6 snRNP 60 kDa protein
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PRPF4-1976H | Recombinant Human PRPF4, GST-tagged | E.coli | Human | GST | C-term-310aa | |
| PRPF4-10144Z | Recombinant Zebrafish PRPF4 | Mammalian Cells | Zebrafish | His |
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| PRPF4-3625R | Recombinant Rhesus monkey PRPF4 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| PRPF4-2825HCL | Recombinant Human PRPF4 293 Cell Lysate | HEK293 | Human | Non |
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| PRPF4-3443R | Recombinant Rhesus Macaque PRPF4 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PRPF4-3443R-B | Recombinant Rhesus Macaque PRPF4 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| PRPF4-4811H | Recombinant Human PRPF4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Prpf4-5147M | Recombinant Mouse Prpf4 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
PRPF4 involved in several pathways and played different roles in them. We selected most pathways PRPF4 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | BUD31,SNRPD2,HSPA2,PRPF31,ZMAT2,SNRPA1,MAGOHB,DDX46,SF3B3,U2AF1L4 |
Protein Function
PRPF4 has several biochemical functions, for example, U4 snRNA binding,U6 snRNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPF4 itself. We selected most functions PRPF4 had, and list some proteins which have the same functions with PRPF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CLIC1,RRP7A,TRIM72,NLRC5,TRAF3IP3,RQCD1,TRIM23,SLC25A4,MAP3K9,UBC |
| U4 snRNA binding | PRPF31,SART3,NHP2L1,DDX39B |
| U6 snRNA binding | DDX39B,LSM2,EIF5A,SART3,PRPF8,LSM8,LSM4,RBM22,LSM7 |
Interacting Protein
PRPF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPF4.
PPIH;SART1;PRPF3;PRPF6;PRPF4B;SART3;USP39;PRPF8;PRPF31
Resources
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References
- Linder, B; Hirmer, A; et al. Identification of a PRPF4 Loss-of-Function Variant That Abrogates U4/U6.U5 Tri-snRNP Integration and Is Associated with Retinitis Pigmentosa. PLOS ONE 9:-(2014).
- Benaglio, P; San Jose, PF; et al. Mutational screening of splicing factor genes in cases with autosomal dominant retinitis pigmentosa. MOLECULAR VISION 20:843-851(2014).
