PROP1
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Official Full Name
PROP paired-like homeobox 1 -
Overview
This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. -
Synonyms
PROP1;PROP paired-like homeobox 1;prophet of Pit1, paired like homeodomain transcription factor;homeobox protein prophet of Pit-1;Homeobox protein prophet of Pit 1;Pituitary specific homeodomain factor;PROP 1;PROP paired like homeobox 1;pituitary-specific homeodomain factor;prophet of Pit1, paired-like homeodomain transcription factor;CPHD2;PROP-1
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PROP1-13437M | Recombinant Mouse PROP1 Protein | Mammalian Cell | Mouse | His |
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| PROP1-7736Z | Recombinant Zebrafish PROP1 | Mammalian Cell | Zebrafish | His |
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| PROP1-2832HCL | Recombinant Human PROP1 293 Cell Lysate | HEK293 | Human | Non |
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| PROP1-1774H | Recombinant Human PROP1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| PROP1-1774H-B | Recombinant Human PROP1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| PROP1-510HFL | Recombinant Full Length Human PROP1 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| Prop1-5142M | Recombinant Mouse Prop1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| PROP1-7136M | Recombinant Mouse PROP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PROP1-7136M-B | Recombinant Mouse PROP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PROP1 involved in several pathways and played different roles in them. We selected most pathways PROP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PROP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PROP1 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding,beta-catenin binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PROP1 itself. We selected most functions PROP1 had, and list some proteins which have the same functions with PROP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | TP73,POLD1,MED12,ERCC6,MEIOB,JARID2B,POU5F3,NOC3L,TLE1,Trl |
| protein binding | TNPO3,RAB39A,PYROXD1,JOSD1,SNX8,MAP1S,WAC,GPR77,PPP1R1A,STT3A |
| RNA polymerase II distal enhancer sequence-specific DNA binding | SFPQ,NFE2L2,BACH2,REL,GZF1,RUVBL2,CREB1,H3F3A,TAL1,MSC |
| protein C-terminus binding | SNF8,VGLL3,SLC9A3R2,SHANK1,PRKAA1,HRAS,ZBTB16,CDK7,SNTG1,LCK |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | SIX3,FUBP1,POU4F1,HCFC1,MEOX2,SIX6,REL,SPI1,NFE2L2,NFKB1 |
| transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding | ARX,ZBTB16,GZF1,PAX4,BACH2,MSC,BACH1 |
| beta-catenin binding | TBL1X,PTPRU,CARM1,TRPC4,KLF4,HDAC6,GRIP1,C,CDH2,RORA |
Interacting Protein
PROP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PROP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PROP1.
AES;HSPA8;AMPH;ATN1;EFEMP1;CNTN1;KCTD1;FAM20C;NCDN
Resources
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References
- Higuchi, M; Kanno, N; et al. GFP-expressing S100 beta-positive cells of the rat anterior pituitary differentiate into hormone-producing cells. CELL AND TISSUE RESEARCH 357:767-779(2014).
- Susa, T; Kato, T; et al. Paired-Related Homeodomain Proteins Prx1 and Prx2 are Expressed in Embryonic Pituitary Stem/Progenitor Cells and May Be Involved in the Early Stage of Pituitary Differentiation. JOURNAL OF NEUROENDOCRINOLOGY 24:1201-1212(2012).
