PRKAG3

  • Official Full Name

    protein kinase, AMP-activated, gamma 3 non-catalytic subunit

  • Overview

    The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.

  • Synonyms

    PRKAG3;protein kinase, AMP-activated, gamma 3 non-catalytic subunit;5-AMP-activated protein kinase subunit gamma-3;AMPK gamma3;AMPK gamma-3 chain;AMPK subunit gamma-3;5-AMP-activated protein kinase, gamma-3 subunit;AMPKG3
Cat.# Product name Source (Host) Species Tag Protein Length Price
Prkag3-426M Recombinant Mouse Prkag3 Protein, His-tagged E.coli Mouse His Val238~Val467
PRKAG3-13356M Recombinant Mouse PRKAG3 Protein Mammalian Cell Mouse His
PRKAG3-2916C Recombinant Chicken PRKAG3 Mammalian Cell Chicken His
PRKAG3-2863HCL Recombinant Human PRKAG3 293 Cell Lysate HEK293 Human Non
PRKAG3-7089M Recombinant Mouse PRKAG3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PRKAG3-7089M-B Recombinant Mouse PRKAG3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PRKAG3 involved in several pathways and played different roles in them. We selected most pathways PRKAG3 participated on our site, such as FoxO signaling pathway,AMPK signaling pathway,Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Insulin resistance RPS6KA3B,PPP2R4,MGEA5,IRS1,G6PC3,SLC2A1,RPS6KA3A,PTENA,SOCS3B,AKT3A
    Adipocytokine signaling pathway CAMKK1,POMC,PPARGC1A,ADIPOQ,TNFRSF1A,SLC2A1,ACSL4,AGRP,ACSL1,RXRBA
    Insulin signaling pathway FBP1B,PRKAG1,ACACB,FLOT2B,SOCS2,HRASA,PHKG1B,PRKACA,PDPK1,RPS6KB1
    Non-alcoholic fatty liver disease (NAFLD) PIK3R1,DDIT3,IRS2,NDUFV3,NDUFB10,PRKAB1,COX6A2,COX6B2,UQCRQ,PRKAG1
    FoxO signaling pathway NLK1,TGFBR1,G6PC2,CCNG2,CCND2A,IRS4,FOXO1A,FOXO1,NLK2,GRB2A
    Circadian rhythm CRY2,BTRC,PRKAG2,PRKAB1,CLOCK,ARNTL,NR1D1,PER1,SKP1,PRKAG1
    Hypertrophic cardiomyopathy (HCM) PRKAA1,ITGB3,TNF,CACNG4,ACTG1,RYR2,CACNG3,IGF1,LMNA,CACNA2D3
    AMPK signaling pathway MTOR,ADIPOR2,EEF2K,PFKFB3,MLYCD,IRS1,GYS2,PRKAB2,CREB3L4,HMGCR
    Oxytocin signaling pathway PLCB2,GNAO1,PPP3CC,CAMK1,PLCB1,CALM1,PRKAG1,NPR1,SRC,PRKAA2

    Protein Function

    PRKAG3 has several biochemical functions, for example, AMP-activated protein kinase activity,ATP binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAG3 itself. We selected most functions PRKAG3 had, and list some proteins which have the same functions with PRKAG3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PIP5KL1,NUBPL,AK5,DQX1,UBE2D1B,PIK3R4,ERN2,FUK,CARKD,KIF3A
    protein kinase binding NR4A3,AXIN1,EEF2,CACNB4,CEP68,CCNE1,BCAR1,NBEA,DCX,PAX6
    AMP-activated protein kinase activity PRKAA1,PRKAB1,ALPK2,PRKAG2,PRKAA2

    Interacting Protein

    PRKAG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAG3.

    Klc1;Klc2

    Resources

    Research Area

    Kinases and Phosphatases in Endothelial Cells
    AMPK (AMP-activated Protein Kinases)

    References

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