PRKAG1
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Official Full Name
protein kinase, AMP-activated, gamma 1 non-catalytic subunit -
Overview
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. -
Synonyms
PRKAG1;protein kinase, AMP-activated, gamma 1 non-catalytic subunit;5-AMP-activated protein kinase subunit gamma-1;AMPK gamma1;AMPK gamma-1 chain;5-AMP-activated protein kinase, gamma-1 subunit;AMPKG;MGC8666
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- MBP
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
PRKAG1 involved in several pathways and played different roles in them. We selected most pathways PRKAG1 participated on our site, such as FoxO signaling pathway,AMPK signaling pathway,Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-alcoholic fatty liver disease (NAFLD) | MAP3K5,SDHD,ITCH,COX7A1,CEBPA,NDUFA11,NDUFS8,NDUFB3,AKT1,NDUFA2 |
| Insulin signaling pathway | LIPE,FBP1A,CALML3,HKDC1,MAPK8A,MAPK8,RPTOR,ACACB,SOCS3B,FLOT1 |
| Hypertrophic cardiomyopathy (HCM) | TPM1,Itga10&Itgb1,ITGA1,CACNA2D2,ACTC1,ATP2A2,ITGA7,ITGA10,ITGB8,ITGA2B |
| AMPK signaling pathway | PRKAA2,PPP2R5C,PIK3R1,PCK1,PFKFB1,PIK3R2,ACACB,HNF4A,ADIPOR2,CRTC2 |
| Circadian rhythm | PRKAA1,PRKAG2,NR1D1,PRKAB2,RORC,BTRC,PRKAG3,NPAS2,PER2,SKP1 |
| Insulin resistance | IRS1,PRKAB1A,NFKBIAA,GSK3AA,SLC2A2,MAPK8A,TNF,CREB3L3A,PRKAB2,PTPN1 |
| Oxytocin signaling pathway | MYLK,CACNA2D1,CALM4,MYL9,PLA2G4D,ELK1,MYL6B,KRAS,CAMK2A,CALM3 |
| Adipocytokine signaling pathway | RELA,SLC2A1,PPARAB,CPT1B,ACSL3A,CPT1A,PRKAA1,MAPK8A,PRKCQ,LEPA |
| FoxO signaling pathway | SGK3,NLK1,TGFB3,PLK2B,PTENA,TNFSF10,FOXO3,PRKAB1A,CCNB1,RAG2 |
Protein Function
PRKAG1 has several biochemical functions, for example, ADP binding,AMP binding,contributes_to AMP-activated protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAG1 itself. We selected most functions PRKAG1 had, and list some proteins which have the same functions with PRKAG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | HSC70,HSPH1,KIF2B,KIT,MCM4,RPS6KA3,ABCG4B,PSMC3,ABCB6A,MCCC1 |
| cAMP-dependent protein kinase activity | PRKACA,AKAP13,PRKAA1,PRKACB,PRKX,PRKACG |
| protein kinase binding | TSACC,HSP90AB1,CDC25B,PARK2,CALM2,CSPG4,DNM2,SYK,CCNYL1,MAPT |
| cAMP-dependent protein kinase regulator activity | PRKAR1AB,PRKAR1B,CXCL10,PRKAR2A,PRKAR2B,PRKAR2AA,PRKAG2,PRKAR1AA,PRKAR2AB,PRKAR1A |
| contributes_to AMP-activated protein kinase activity | PRKAB2 |
| ADP binding | VCP,ERN1,MYO7A,MYO18A,ME1,GLUD1,PRKAG2,ACTA1,MYO3A,APAF1 |
| protein binding | CD1A,GDF5,FAM124B,PXMP4,MYF5,CPT1B,PAX6,EEF1A1,XPO6,ISG15 |
| AMP binding | FBP1,PRKAG2,CYB5R3,ACSS2,PYGL,PYGM,PRPS2,APRT,ACSS1,PRPS1 |
| protein kinase activity | MAP4K6,PLK2B,RAF1,PRKCHA,Fert2,AURKC,MAP3K3,NRBP1,PRKD2,CDK8 |
Interacting Protein
PRKAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAG1.
PRKAA1;PRKAB2;PRKAB1
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References
- Lindholm-Perry, AK; Kuehn, LA; et al. DNA polymorphisms and transcript abundance of PRKAG2 and phosphorylated AMP-activated protein kinase in the rumen are associated with gain and feed intake in beef steers. ANIMAL GENETICS 45:461-472(2014).
- Zambonelli, P; Davoli, R; et al. SNPs detection in DHPS-WDR83 overlapping genes mapping on porcine chromosome 2 in a QTL region for meat pH. BMC GENETICS 14:-(2013).
