PREB
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Official Full Name
prolactin regulatory element binding -
Overview
Prolactin regulatory element-binding protein is a protein that in humans is encoded by the PREB gene. -
Synonyms
PREB;prolactin regulatory element binding;prolactin regulatory element-binding protein;Mammalian guanine nucleotide exchange factor mSec12;Prolactin regulatory element binding protein;SEC12;C85705
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Myc
- Avi
- Fc
- DDK
Involved Pathway
PREB involved in several pathways and played different roles in them. We selected most pathways PREB participated on our site, such as Asparagine N-linked glycosylation,COPII (Coat Protein 2) Mediated Vesicle Transport,Cargo concentration in the ER, which may be useful for your reference. Also, other proteins which involved in the same pathway with PREB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Membrane Trafficking | CTSZ,SNX9,COPB2,PUM1,SNAPIN,COPZ1,TPD52L1,DTNBP1B,DNASE2,COPG |
| ER to Golgi Anterograde Transport | PPP6R1,SEC16B,SEC22C,AREG,TMED2,CTSZ,NAPG,TFG,PPP6R3,CTSC |
| Asparagine N-linked glycosylation | ZNF408,GOLGA2,MCFD2,SERPINA1L,TRAPPC3,ANKRD28,ST6GAL2B,SEC23A,LMAN2,MIA3 |
| Post-translational protein modification | MAN1B1,TMED10,SEC22A,ADAMTS1,ARSF,SPON1A,MCFD2,MUC5AC,MPDU1,CNIH |
| Metabolism of proteins | TMED10,ADAMTS1,LTF,CBX8,RNF2,TOMM20,MGAT4B,THSD1,SLC35A1,TRAPPC6B |
| Cargo concentration in the ER | SEC24A,MIA3,AREG,CTSC,CNIH3,LMAN2L,LMAN2,SEC23A,CTSZ,CTAGE5 |
| COPII (Coat Protein 2) Mediated Vesicle Transport | TMED10,NAPG,TRAPPC2,CTSC,PPP6R3,TRAPPC6B,SEC24A,TRAPPC6A,LMAN2,LMAN2L |
| IRE1alpha activates chaperones | TPP1,DNAJB9,ADD1,CTDSP2,SEC61B,ASNA1,SEC63,WIPI1,CXXC1,DDX11 |
Protein Function
PREB has several biochemical functions, for example, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PREB itself. We selected most functions PREB had, and list some proteins which have the same functions with PREB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | AIFM1,FOXD1L,DRGX,SALL3,TOX2,RYBPA,ISX,POLR1D,PAX1,KDM2B |
Interacting Protein
PREB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PREB here. Most of them are supplied by our site. Hope this information will be useful for your research of PREB.
HSP90AB1;HSP90AB1;Preb;NUDC;vpu
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References
- Weissman, JT; Plutner, H; et al. The mammalian guanine nucleotide exchange factor mSec12 is essential for activation of the Sar1 GTPase directing endoplasmic reticulum export. TRAFFIC 2:465-475(2001).
- Schweppe, RE; Gutierrez-Hartmann, A; et al. Pituitary Ets-1 and GABP bind to the growth factor regulatory sites of the rat prolactin promoter. NUCLEIC ACIDS RESEARCH 29:1251-1260(2001).
