PRDM4
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Official Full Name
PR domain containing 4 -
Overview
The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. -
Synonyms
PRDM4;PR domain containing 4;PR domain zinc finger protein 4;PFM1;PR domain-containing protein 4;PR-domain zinc-finger protein PFM1;MGC45046
Recombinant Proteins
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Human
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PRDM4-13317M | Recombinant Mouse PRDM4 Protein | Mammalian Cells | Mouse | His |
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| PRDM4-3588R | Recombinant Rhesus monkey PRDM4 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| PRDM4-4656R | Recombinant Rat PRDM4 Protein | Mammalian Cells | Rat | His |
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| PRDM4-6583Z | Recombinant Zebrafish PRDM4 | Mammalian Cells | Zebrafish | His |
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| PRDM4-2885HCL | Recombinant Human PRDM4 293 Cell Lysate | HEK293 | Human | Non |
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| PRDM4-3406R | Recombinant Rhesus Macaque PRDM4 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PRDM4-3406R-B | Recombinant Rhesus Macaque PRDM4 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| PRDM4-4315R | Recombinant Rat PRDM4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PRDM4-4315R-B | Recombinant Rat PRDM4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PRDM4-7067M | Recombinant Mouse PRDM4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PRDM4-7067M-B | Recombinant Mouse PRDM4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PRDM4 involved in several pathways and played different roles in them. We selected most pathways PRDM4 participated on our site, such as Neurotrophin signaling pathway,Signal Transduction,Signalling by NGF, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signalling by NGF | PCSK5,RTN4,KIDINS220B,ARHGEF1B,DNAL4B,DNAL4A,RTN4A,RIT1,RIT2,OMG |
| Signal Transduction | ARHGAP24,CHRDL1,CCNT2A,FGD2,DTX2,GPR55A,OR52J3,LGR6,EMR2,MYO7A |
| p75(NTR)-mediated signaling | OMG,MAGEH1,ZNF274,RTN4,BEX1,NDN,RTN4R |
| Neurotrophin signaling pathway | IRS1,RAP1B,MAPK8,ABL1,MAP2K2,TRP53,ZFP110,ARHGDIB,NGFRAP1,RAPGEF1 |
| p75 NTR receptor-mediated signalling | RTN4A,LINGO1B,OMG,RTN4,AATF,LINGO1,ARHGEF1B |
Protein Function
PRDM4 has several biochemical functions, for example, DNA binding,death receptor binding,histone methyltransferase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDM4 itself. We selected most functions PRDM4 had, and list some proteins which have the same functions with PRDM4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZFP146,NHEJ1,ZFP28,POLR2B,CENPW,MAFA,HOXB13A,CHES1,HOXD13A,LHX1A |
| death receptor binding | RIPK1,FASLG,MYD88,CFLAR,Casp3,CASP8,FEM1B,BID,FADD,TMBIM1 |
| histone methyltransferase binding | CBX1,NOP56,CBX3 |
| methyltransferase activity | METTL4,TRMT10C,METTL22,PRMT9,ALDH1L1,KIAA1456,ASMT2,DIMT1,SMYD4,GAMT |
| zinc ion binding | BAZ1A,FTR14,TRAIP,CBLB,USP51,NR2F1B,CPO,PRICKLE2B,CPXM1,S100A9 |
| protein binding | DLGAP1,PGM2,SHD,RFC2,GIMAP7,RIPPLY3,OSR2,KRT83,AMY1A,UBL7 |
Interacting Protein
PRDM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDM4.
MSRB3;CTNNBL1;EIF4E;SMAD3;msbA
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References
- Dai, QS; Shah, AA; et al. A Truncated Progesterone Receptor (PR-M) Localizes to the Mitochondrion and Controls Cellular Respiration. MOLECULAR ENDOCRINOLOGY 27:741-753(2013).
- Petukhova, NV; Gasanova, TV; et al. Immunogenicity and Protective Efficacy of Candidate Universal Influenza A Nanovaccines Produced in Plants by Tobacco Mosaic Virus-based Vectors. CURRENT PHARMACEUTICAL DESIGN 19:5587-5600(2013).
