PPP3CB
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Official Full Name
protein phosphatase 3, catalytic subunit, beta isozyme -
Overview
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP3CB gene. -
Synonyms
PPP3CB;protein phosphatase 3, catalytic subunit, beta isozyme;CALNB, protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta);serine/threonine-pro
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPP3CB-3813H | Recombinant Human PPP3CB protein, His-tagged | E.coli | Human | His | 1-525 aa | |
| PPP3CB-13267M | Recombinant Mouse PPP3CB Protein | Mammalian Cells | Mouse | His |
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| PPP3CB-2226C | Recombinant Chicken PPP3CB | Mammalian Cells | Chicken | His |
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| PPP3CB-2579Z | Recombinant Zebrafish PPP3CB | Mammalian Cells | Zebrafish | His |
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| PPP3CB-4640R | Recombinant Rat PPP3CB Protein | Mammalian Cells | Rat | His |
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| PPP3Cb-1239M | Recombinant Mouse PPP3Cb protein, His-tagged | E.coli | Mouse | His&GST | Thr360~Gln525 |
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| PPP3CB-1973H | Recombinant Human PPP3CB Protein, His&GST-tagged | E.coli | Human | His&GST | Thr360-Gln524 |
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| PPP3CB-4299R | Recombinant Rat PPP3CB Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PPP3CB-4299R-B | Recombinant Rat PPP3CB Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PPP3CB-7041M | Recombinant Mouse PPP3CB Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PPP3CB-7041M-B | Recombinant Mouse PPP3CB Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PPP3CB involved in several pathways and played different roles in them. We selected most pathways PPP3CB participated on our site, such as MAPK signaling pathway,Calcium signaling pathway,cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3CB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | PIK3CB,FCGR4,MAP3K7,MAPK10,SFPI1,cgr2b,SIRP-BETA,NFKB1,FOSL2,TNFRSF1A |
| Renin secretion | ACE,CALM4,PPP3R1,PLCB4,PTGER2,GUCY1B3,PRKACA,PRKACG,REN,LOC100328615 |
| cGMP-PKG signaling pathway | AKT1,GUCY1A3,ROCK1,PLCB2,MAP2K2,SLC25A6,MEF2A,PDE3A,ROCK2,GNAI1 |
| VEGF signaling pathway | MAPK12A,RAC3B,PIK3CD,PIK3R5,PLA2G4D,PIK3R3A,RAC1A,PTK2AA,PPP3CCB,SPHK1 |
| Dopaminergic synapse | ATF6B,DRD1A,PRKACB,PPP2R3C,CAMK2A,CAMK2G,GNB3,GRIA2,GRIA1,DDC |
| Oocyte meiosis | ESPL1,CDC27,CDK1,CALM3A,PPP2R5C,CPEB2,SMC1A,PPP1CB,INSB,PPP3R1 |
| Wnt signaling pathway | LEF1,DKK4,AXIN2,WIF1,PRKCA,CAMK2D2,RAC3A,PLCB3,WNT11,SFRP2 |
| T cell receptor signaling pathway | MAP2K2,CD3D,GSK3B,IKBKB,CD40LG,RAF1,MAPK11,DLG1,MUC1,PAK6 |
| B Cell Receptor Signaling Pathway | NFKBIA,CD81,DUSP4,RAC2,GRB2,HDAC5,MAPK1,BLK,BANK1,PPP3R1 |
Protein Function
PPP3CB has several biochemical functions, for example, calcium ion binding,calcium-dependent protein serine/threonine phosphatase activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3CB itself. We selected most functions PPP3CB had, and list some proteins which have the same functions with PPP3CB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphoprotein phosphatase activity | PTPRZ1,PPP3CCA,PPM1H,PPP1CBL,PTPN4A,PPM1BB,PPP4CB,CTDSPL2B,DUSP26,PTPN11 |
| protein phosphatase 2B binding | AKAP5,ATP2B4,SOD1,AKAP1,BAD,MYOZ2,SLC9A1 |
| calmodulin binding | PHKG2,CAMK2A,UPF3B,MAPKAPK5,MKNK2A,IQCB1,SLC8A2,SNTB2,KCNH1,SLC14A2 |
| calcium-dependent protein serine/threonine phosphatase activity | PPP3R1,NETO2,CAMK2G |
| protein heterodimerization activity | HIST1H3A,USF2,HIST1H2BL,ATF2,DR1,MPP7,HIST1H2BF,DMRT3,TENM1,HIST1H2B7 |
| drug binding | DRD1A,GLRB,SRP54B,DRD1,CHRNA7,IL2RA,PPARA,UGT1A7,CHRNA2,FOLR2 |
| calcium ion binding | TBC1D9B,CDH4,CDH10A,PCDHGC4,CAPRIN1A,CETN4,CRB2A,PLA2G4A,MBL2,PRF1 |
| hydrolase activity | MAN1A,F2RL1.1,GM5077,GGT7,MOV10B.2,DDX39AA,PPTC7A,STAMBPA,ADAMTS7,DOM3Z |
| calmodulin-dependent protein phosphatase activity | PPP3CA,PPM1F,PPM1A |
Interacting Protein
PPP3CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3CB.
Akap5;NFATC1;Akap6;Ppp3r1;Hmga2;Ywhae;Dlg4;Map3k5
Resources
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References
- Vasu, S; McClenaghan, NH; et al. Cellular responses of novel human pancreatic beta-cell line, 1.1B4 to hyperglycemia. ISLETS 5:170-177(2013).
- Polovkova, OG; Makeeva, OA; et al. Expression Profiles of Calcineurin Pathway Genes in Myocardium in Relation to Ischemic Heart Remodeling in Humans. MOLECULAR BIOLOGY 47:382-388(2013).
