PPP2R3A
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Official Full Name
protein phosphatase 2, regulatory subunit B, alpha -
Overview
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B/PR61, and B/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B family. The B family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
PPP2R3A;protein phosphatase 2, regulatory subunit B, alpha;PPP2R3, protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 72), alpha isoform and (PR 130), beta isoform , protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha;serine/t
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPP2R3A-1918H | Recombinant Human PPP2R3A, His-tagged | E.coli | Human | His | 801-1150aa | |
| PPP2R3A-3573R | Recombinant Rhesus monkey PPP2R3A Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| PPP2R3A-2921HCL | Recombinant Human PPP2R3A 293 Cell Lysate | HEK293 | Human | Non |
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| PPP2R3A-1254H | Recombinant Human PPP2R3A Protein (M786-F1070), Tag Free | E.coli | Human | Non | M786-F1070 |
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| PPP2R3A-1255H | Recombinant Human PPP2R3A Protein (M786-F1070), His tagged | E.coli | Human | His | M786-F1070 |
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| PPP2R3A-2621H | Recombinant Human PPP2R3A Protein, His-tagged | E.coli | Human | His | Asp827-Glu1150 |
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| PPP2R3A-3391R | Recombinant Rhesus Macaque PPP2R3A Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| PPP2R3A-3391R-B | Recombinant Rhesus Macaque PPP2R3A Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
PPP2R3A involved in several pathways and played different roles in them. We selected most pathways PPP2R3A participated on our site, such as mRNA surveillance pathway,Sphingolipid signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dopaminergic synapse | SLC18A1,CLOCK,KCNJ3,GNG2,GNB4,SCN1A,CALM4,PPP2CA,ATF6B,ITPR1 |
| Adrenergic signaling in cardiomyocytes | GNAI1,Adcy4,CREM,ACTC1,CACNA1SA,CREB3L1,CACNG1,PPP2R5E,ATP2B4,CALM3A |
| PIK-Akt signaling pathway | NR4A1,PDGFRA,TEK,RPS6KB1,ITGA10,PHLPP1,TCL1A,PIK3R1,PCK2,PKN1 |
| mRNA surveillance pathway | SMG6,NXF2,PABPC1A,PPP2R2A,PPP2R5B,PPP2R5EB,MSI2B,NXT2,PPP2CB,FIP1L1B |
| Sphingolipid signaling pathway | NFKB1,PRKCG,HRAS,NOS3,DEGS2,SMPD2,PLCB1,S1PR2,PPP2CA,PPP2R5D |
| AMPK signaling pathway | PPP2R2C,SCD,PIK3R5,EEF2K,RPTOR,SCD5,PIK3R1,PIK3R2,PRKAG1,FBP1 |
Protein Function
PPP2R3A has several biochemical functions, for example, calcium ion binding,protein binding,protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R3A itself. We selected most functions PPP2R3A had, and list some proteins which have the same functions with PPP2R3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding, bridging | CUX1,FKBP4,CAV2,CAV1,VPS18,EVPL,GOLGA5,SPRR1B,DSP,TRIM22 |
| protein binding | CECR2,LRRFIP1,FLAD1,MOBKL2B,C6orf108,FAM20C,CAMTA2,ZKSCAN5,ITGA2B,GALNT3 |
| calcium ion binding | CBLC,FBN2B,ANXA11A,ANXA5,LRP1,FKBP7,FSTL4,BRAF,RHOT2,DUOX2 |
| protein phosphatase type 2A regulator activity | PPP2R1B,pab1,PPP2R1A,ARPP19,PPP2R5EB,EIF2AK2,PPP2R5EA,PPP2R5D,PPME1,PPP2R2C |
Interacting Protein
PPP2R3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R3A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R3A.
PPP2R1A;PPP2R1B;PPP5C;ATXN7L2;Ppp2r1a;SLX4
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References
- Becsi, B; Dedinszki, D; et al. Identification of protein phosphatase interacting proteins from normal and UVA-irradiated HaCaT cell lysates by surface plasmon resonance based binding technique using biotin-microcystin-LR as phosphatase capturing molecule. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 138:240-248(2014).
- Peng, HY; Chen, GD; et al. Spinal SIRP alpha 1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats. PAIN 153:1042-1053(2012).
