PPP1R13L
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Official Full Name
protein phosphatase 1, regulatory subunit 13 like -
Overview
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53. -
Synonyms
PPP1R13L;protein phosphatase 1, regulatory subunit 13 like;protein phosphatase 1, regulatory (inhibitor) subunit 13 like;relA-associated inhibitor;IASPP;RAI;protein iASPP;PPP1R13B-like protein;retinoic acid induced 4;inhibitor of ASPP protein;NF
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPP1R13L-1903H | Recombinant Human PPP1R13L, His-tagged | E.coli | Human | His | 481-829aa | |
| PPP1R13L-2249Z | Recombinant Zebrafish PPP1R13L | Mammalian Cell | Zebrafish | His |
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| PPP1R13L-1399HCL | Recombinant Human PPP1R13L cell lysate | Human | Non |
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Involved Pathway
PPP1R13L involved in several pathways and played different roles in them. We selected most pathways PPP1R13L participated on our site, such as Integrated Pancreatic Cancer Pathway,TNF-alpha/NF-kB Signaling Pathway,p53 pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1R13L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF-alpha/NF-kB Signaling Pathway | KTN1,COMMD1,PFDN2,TRAIP,RNF216,NKIRAS2,MCC,COPS3,DPF2,G3BP2 |
| p53 pathway | RASSF1,CSE1L,HUWE1,KAT8,TTC5,SMYD2,FBXO11,TRIM28,E4F1,NEDD8 |
| Integrated Pancreatic Cancer Pathway | MST1,FST,LEFTY1,RAPGEF3,CASP12,NOXA1,RB1CC1,FKBP3,IL11,TOP1 |
Protein Function
PPP1R13L has several biochemical functions, for example, identical protein binding,protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1R13L itself. We selected most functions PPP1R13L had, and list some proteins which have the same functions with PPP1R13L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | NOD1,SRI,SYNE1,SDCBP,ZNF703,TRAF2,UHRF1,MUL1,SKP2,BLOC1S6 |
| protein binding | CPS1,NUAK1,ABCG8,C2orf62,SPP1,BTK,NR2C2,GTPBP3,PIDD1,PVRL2 |
| transcription factor binding | PPP1R13BB,ARNT,WWP2,PPARG,HES2,PDCD11,CSNK2B,TCF3,PSMD4,DNAJA3 |
| transcription corepressor activity | PAWR,NR0B2A,DAXX,FEV,NEUROD2,KDM5B,LHX9,AES,TBL1Y,ZMYND11 |
Interacting Protein
PPP1R13L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1R13L here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1R13L.
TP53;PPP1CA;RAN
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References
- Notari, M; Hu, Y; et al. iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E973-E981(2015).
- Offenmuller, S; Ravindranath, Y; et al. Focused screening of a panel of cancer-related genetic polymorphisms reveals new susceptibility loci for pediatric acute lymphoblastic leukemia. PEDIATRIC BLOOD & CANCER 61:1411-1415(2014).
