PPP1CA
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Official Full Name
protein phosphatase 1, catalytic subunit, alpha isozyme -
Overview
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PPP1CA;protein phosphatase 1, catalytic subunit, alpha isozyme;PPP1A, protein phosphatase 1, catalytic subunit, alpha isoform;serine/threonine-protein phosphatase PP1-alpha catalytic subunit;PP 1A;PP1alpha;protein phosphatase 1, catalytic subunit,
Recombinant Proteins
- Human
- Mouse
- Rat
- Dog
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- His
- Non
- His&Myc
- His&Fc&Avi
Involved Pathway
PPP1CA involved in several pathways and played different roles in them. We selected most pathways PPP1CA participated on our site, such as mRNA surveillance pathway,cGMP-PKG signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | PRKAG1,PRKCZ,PTPN11A,TBC1D4,NFKBIAB,PPP2R4,GSK3AA,PCK2,MTOR,SLC27A3 |
| Oxytocin signaling pathway | PIK3CG,PTGS2,CACNG6,RGS2,PRKCG,MYLK,OXT,NFATC4,NFATC3,PPP3R1 |
| Regulation of Actin Cytoskeleton | WASL,GNA13A,PIK3CB,VAV3B,PPP1CBL,MYL5,PIK3R3B,ACTN4,FGF16,ITGB3 |
| Oocyte meiosis | CCNB2,SLK,ADCY1A,PKMYT1,CDC26,INSB,YWHAE1,ANAPC4,CCNE2,YWHAH |
| Dopaminergic synapse | GNG11,CAMK2A,PRKCG,MAPK13,CREB3,CALY,GNAI1,GNGT1,KCNJ3,GSK3B |
| Hippo signaling pathway | GDF7,AJUBA,PARD6A,ACTG1,WNT11,DLG3,PRKCZ,PPP2R2C,GDF5,FZD5 |
| Focal adhesion | PIK3R2,MYLPF,PRKCG,BIRC2,VCL,VEGFAA,MAPK1,PDPK1B,AKT2,PRKCB |
| Long-term potentiation | ARAF,PPP3R2,RPS6KA6,PRKACB,PRKACA,PRKACG,CAMK4,GRIN1,RAF1,PLCB4 |
| Alcoholism | SLC6A3,H3F3B,HIST1H2AO,CAMKK2,CREB5,HIST1H4E,HIST1H4J,HIST2H2BB,HDAC7A,H2BFWT |
Protein Function
PPP1CA has several biochemical functions, for example, ATP binding,GTP binding,butyrate-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1CA itself. We selected most functions PPP1CA had, and list some proteins which have the same functions with PPP1CA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ASXL1,C6AST4,PDLIM5A,CPEB1B,TRIM35,NDUFS8,ZIC5,GTSF1L,CAT,FBXO40.1 |
| GTP binding | OLA1,GNL1,RAP1AB,ARF3,REM1,RAB35B,PCK2,ARL5C,RHOQ,RND1 |
| butyrate-CoA ligase activity | ACSM2B,ACSM5,ACSM4,Acsm2a,ACSM1,ACSM2,AACS,ACSM3 |
| ATP binding | ABCA13,MYO7A,PBK,PKZ,TTL,PTK6,ATP1A3,DHX58,TRAP1,UBE2B |
Interacting Protein
PPP1CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1CA.
TP53BP2;CSRNP2;RB1;PPP1R13B
Resources
Research Area
Phosphatases and RegulatorsPhosphatases in the Akt Pathway
Adherens Junction Proteins in Endothelial Cells
Adherens Junction Proteins in VSMC
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References
