PPOX
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Official Full Name
protoporphyrinogen oxidase -
Overview
This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. -
Synonyms
PPOX;protoporphyrinogen oxidase;variegate porphyria , VP;PPO;VP;V290M;MGC8485
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- Human Cells
- HEK293T
- His
- His&GST
- Non
- His&SUMO
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PPOX involved in several pathways and played different roles in them. We selected most pathways PPOX participated on our site, such as Porphyrin and chlorophyll metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPOX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Porphyrin and chlorophyll metabolism | ALAS2,UROS,UGT1A6B,HMOX2A,HEPH,HCCSA.1,MMAB,UGT1A9,UGT2B15,UGT1A2 |
| Metabolic pathways | EXTL3,ITPK1,MAT2AA,G6PC3,TDO2A,EARS2,PTGES2,PLA2G2A,CYP2J5,UAP1L1 |
Protein Function
PPOX has several biochemical functions, for example, flavin adenine dinucleotide binding,oxygen-dependent protoporphyrinogen oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPOX itself. We selected most functions PPOX had, and list some proteins which have the same functions with PPOX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| flavin adenine dinucleotide binding | ACADSB,DUS1L,TXNRD2,CHDH,CRY-DASH,TXNRD1,MTO1,CYB5R3,NOS1,DMGDH |
Interacting Protein
PPOX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPOX here. Most of them are supplied by our site. Hope this information will be useful for your research of PPOX.
HAP1;IMMT;COPS5;Alas2;Fech;Cpox;Slc25a4;Ppox;Slc25a5;Vdac2;Abcb7;Tfrc;Glrx5;Steap3;Sfxn1;Tmem14c;Slc25a11;Abcb10;Sucla2
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