PPIP5K1
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Official Full Name
diphosphoinositol pentakisphosphate kinase 1 -
Overview
This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15. -
Synonyms
PPIP5K1;diphosphoinositol pentakisphosphate kinase 1;HISPPD2A, histidine acid phosphatase domain containing 2A;inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1;IPS1;KIAA0377;VIP1;IP6K;Histidine acid phosphatase domain-containing protein 2A;hsVIP1;Inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinase 1;Inositol pyrophosphate synthase 1;InsP6 and PP IP5 kinase 1;IP6 kinase;PP IP5 kinase 1;VIP1 homolog;insP6 and PP-IP5 kinase 1;histidine acid phosphatase domain containing 2A;HISPPD2A
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPIP5K1-13788H | Recombinant Human PPIP5K1, His-tagged | E.coli | Human | His | 1-301a.a. | |
| PPIP5K1-13192M | Recombinant Mouse PPIP5K1 Protein | Mammalian Cells | Mouse | His |
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| PPIP5K1-793HCL | Recombinant Human PPIP5K1 cell lysate | Human | Non |
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| Ppip5k1-1966M | Recombinant Mouse Ppip5k1 Protein, His-tagged | E.coli | Mouse | His | Ala514-Thr857 |
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| PPIP5K1-2612H | Recombinant Human PPIP5K1 Protein, His-tagged | E.coli | Human | His | Met1-Gly326 |
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| PPIP5K1-6988M | Recombinant Mouse PPIP5K1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PPIP5K1-6988M-B | Recombinant Mouse PPIP5K1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PPIP5K1 involved in several pathways and played different roles in them. We selected most pathways PPIP5K1 participated on our site, such as Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPIP5K1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | PLCD1B,PIK3R2,IMPA2,PLCE1,PIK3CD,CALM1,PI4K2B,PIP4K2B,DGKE,PIP5K1BB |
Protein Function
PPIP5K1 has several biochemical functions, for example, ATP binding,acid phosphatase activity,diphosphoinositol-pentakisphosphate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPIP5K1 itself. We selected most functions PPIP5K1 had, and list some proteins which have the same functions with PPIP5K1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol hexakisphosphate 5-kinase activity | IP6K3,IP6K2,IP6K1,PPIP5K2 |
| diphosphoinositol-pentakisphosphate kinase activity | PPIP5K2 |
| inositol hexakisphosphate 3-kinase activity | IP6K2,PPIP5K2,IP6K3,IP6K1 |
| inositol hexakisphosphate 1-kinase activity | IP6K1,IP6K2,PPIP5K2,IP6K3 |
| ATP binding | AK5L,KIF18A,SUPV3L1,BAZ1B,TAOK3,MAK,NTRK3,ACSS1,CAMKK1A,ORC1L |
| acid phosphatase activity | PPIP5K2,ACP5,ACPP,ACP2,ACP5B,ACP5A,ACP6,MINPP1,MINPP1A,ACP1 |
Interacting Protein
PPIP5K1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPIP5K1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPIP5K1.
Resources
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References
- Williams, SP; Gillaspy, GE; et al. Biosynthesis and possible functions of inositol pyrophosphates in plants. FRONTIERS IN PLANT SCIENCE 6:-(2015).
- Desai, M; Rangarajan, P; et al. Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plants. PLANT JOURNAL 80:642-653(2014).
