PPFIA1
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Official Full Name
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -
Overview
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
PPFIA1;protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1;liprin-alpha-1;LIP.1;LIPRIN;Liprin alpha1;LAR interacting protein 1;LIP 1;LIP1;PPFIA 1;Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 1;Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 1;PTPRF interacting protein alpha 1;LIP-1;Liprin-alpha1;OTTHUMP00000235552;OTTHUMP00000235553;LAR-interacting protein 1;PTPRF-interacting protein alpha-1;protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPFIA1-1879H | Recombinant Human PPFIA1, GST-tagged | E.coli | Human | GST | N-term-350aa | |
| PPFIA1-8113H | Recombinant Human PPFIA1 protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Ala250 |
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| PPFIA1-2599H | Recombinant Human PPFIA1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Ppfia1-5035M | Recombinant Mouse Ppfia1 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| PPFIA1-6599H | Recombinant Human PPFIA1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| PPFIA1-6640H | Recombinant Human PPFIA1 Protein (Met1-Ala250), N-His tagged | E.coli | Human | His | Met1-Ala250 |
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Involved Pathway
PPFIA1 involved in several pathways and played different roles in them. We selected most pathways PPFIA1 participated on our site, such as Acetylcholine Neurotransmitter Release Cycle,Dopamine Neurotransmitter Release Cycle,Glutamate Neurotransmitter Release Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPFIA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neurotransmitter Release Cycle | CPLX1,PPFIA2,LIN7B,ARL6IP5B,ARL6IP5,ARL6IP5A,SLC6A11,SLC1A2A,SLC17A7A,SLC1A2B |
| Norepinephrine Neurotransmitter Release Cycle | SNAP25A,SYT1A,CPLX2L,PPFIA4,SNAP25B,RAB3AB,STXBP1A,RAB3AA,PPFIA2,BZRAP1 |
| Dopamine Neurotransmitter Release Cycle | LIN7C,Apba1,RERG,CPLX1,PPFIA4,SYN1,LIN7A,PPFIA2,UNC13B,SYN3 |
| Transmission across Chemical Synapses | SYN3,NCALDA,SLC1A7A,SYT1A,SLC17A7A,GABRR2A,PICK1,RERG,RAB3AA,CPLX2L |
| Serotonin Neurotransmitter Release Cycle | SYN2,SYN3,CPLX1,PPFIA2,RERG,SYN1,PPFIA4 |
| Glutamate Neurotransmitter Release Cycle | STXBP1A,RERG,SLC1A7A,SLC17A7A,PPFIA4,PPFIA2,SLC1A2A,ARL6IP5,GLS2B,UNC13B |
| Neuronal System | KCNJ8,STXBP1A,KCNC4,KCNH8,PICK1,PANX2,PPFIA2,KCNG3,KCNJ1A.3,KCNG1 |
| Acetylcholine Neurotransmitter Release Cycle | BZRAP1,RAB3AB,PPFIA4,SLC18A3A,CHAT,RAB3AA,STXBP1A,RERG,CPLX2L,SNAP25B |
Protein Function
PPFIA1 has several biochemical functions, for example, protein binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPFIA1 itself. We selected most functions PPFIA1 had, and list some proteins which have the same functions with PPFIA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PHF20L1,KLK8,NSMCE2,ZSCAN10,SBDS,ABCA1,F10,SNRPD3,CDX1,HMGB4 |
| signal transducer activity | FLNA,OLFCH1,GNAL,C18orf32,PTGER2A,GPR152,OLFCS1,VMN1R50,GNGT1,APOL3 |
Interacting Protein
PPFIA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPFIA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPFIA1.
PPP2CA;PPP2R5D;MBIP;PPP2R1A;DTNB;TXLNA;CCNH
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References
- Unoki, M; Shen, JC; et al. Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. JOURNAL OF BIOLOGICAL CHEMISTRY 281:34677-34686(2006).
