PPEF2
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Official Full Name
protein phosphatase, EF-hand calcium binding domain 2 -
Overview
This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. -
Synonyms
PPEF2;protein phosphatase, EF-hand calcium binding domain 2;serine/threonine-protein phosphatase with EF-hands 2;PPP7CB;protein phosphatase 7;catalytic subunit;beta isozyme;protein phosphatase with EF hands 2;protein phosphatase, EF hand calcium-b
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPEF2-13171M | Recombinant Mouse PPEF2 Protein | Mammalian Cells | Mouse | His |
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| PPEF2-6975M | Recombinant Mouse PPEF2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PPEF2-6975M-B | Recombinant Mouse PPEF2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PPEF2 involved in several pathways and played different roles in them. We selected most pathways PPEF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PPEF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PPEF2 has several biochemical functions, for example, Hsp70 protein binding,Hsp90 protein binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPEF2 itself. We selected most functions PPEF2 had, and list some proteins which have the same functions with PPEF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Hsp90 protein binding | AHR,HIF1A,STUB1,HDAC6,FKBP6,USP19,UNC45B,ERN1,GBP1,UNC45A |
| protein serine/threonine phosphatase activity | ILKAP,MTMR3,PPM1N,PDP2,PPM1G,PPP1R3D,PPM1K,PPP1CC,PPP4C,DULLARD |
| hydrolase activity | LYZ1,PPM1AB,PSMA6A,ATP1A1A.4,NOTUM1B,Aadacl3,KLK13,F9B,ACTG2,INPP5L |
| metal ion binding | ZFC3H1,CNOT4B,CSGALNACT1,ZEB2B,PRDM13,NAIP6,EXT1A,B4GALT3,FAH,PRICKLE2B |
| phosphoprotein phosphatase activity | CTDSPL2B,DUSP22B,PPP1R3B,PTPRK,PPP1CAB,DUSP22A,PTPN2A,PTPREB,TIMM50,PTPRQ |
| mitogen-activated protein kinase kinase kinase binding | MAP2K1,MAPK9,MAPK1,CDC42,TRAF6,TCF3,MAPK8IP3,STK38,CDC37,TRAF2 |
| manganese ion binding | ABL2,B4GALT7,PAPOLA,B4GALT1,PPM1B,GLUL,GYLTL1B,PPM1NB,DCP2,PPM1M |
| Hsp70 protein binding | PPID,CDK1,FAM119A,PACRG,TSACC,ERN1,GPR37,DNAJA1,C11orf73,L7RN6 |
| calcium ion binding | CLGN,PCDH2AB9,CALML3,PLSCR2,PCDH2AB11,CAPN3A,SPNA2,S100A10B,MYL7,CIB1 |
Interacting Protein
PPEF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPEF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPEF2.
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References
- Dovega, R; Tsutakawa, S; et al. Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A. PLOS ONE 9:-(2014).
- Yamaguchi, M; et al. The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways. APOPTOSIS 18:1145-1153(2013).
