PPAT
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Official Full Name
phosphoribosyl pyrophosphate amidotransferase -
Overview
The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. -
Synonyms
PPAT;phosphoribosyl pyrophosphate amidotransferase;amidophosphoribosyltransferase;GPAT;PRAT;Amidophosphoribosyltransferase [Precursor];ATASE;Glutamine phosphoribosylpyrophosphate amidotransferase;Glutamine PRPP amidotransferase;glutamine phosphoribosylpyrophosphatate amidotransferase
Recombinant Proteins
- Human
- E.coli
- Chicken
- Rat
- Rhesus macaque
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- HEK293
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PPAT involved in several pathways and played different roles in them. We selected most pathways PPAT participated on our site, such as Purine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | CECR1,PRPS2,POLR3K,PNPT1,NT5E,ITPA,ENTPD1,URAD,PRPS1,GUCY2F |
| Alanine, aspartate and glutamate metabolism | ADSSL1,NAT8L,GLULC,GOT2B,ASL,DDO,AGXT2,GPT2,ADSL,AGXT |
| Metabolic pathways | ATP5A1,CYP3A25,MAT2AA,CYP2B6,AFMID,ATP5G3B,B4GALT4,CMPK,LASS5,MCAT |
Protein Function
PPAT has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,amidophosphoribosyltransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPAT itself. We selected most functions PPAT had, and list some proteins which have the same functions with PPAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | NR1D1,SORBS2,TRIM35-23,ZFP451,ZFP259,STS,TIMM8A2,LRP2,NUFIP1,APLF |
| 4 iron, 4 sulfur cluster binding | DPYDB,BRIP1,NUBPL,CDKAL1,ISCA2,IREB2,POLD1,DNA2,NFU1,DDX11 |
Interacting Protein
PPAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPAT here. Most of them are supplied by our site. Hope this information will be useful for your research of PPAT.
ATXN1;EPT1
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