PPARGC1A
-
Official Full Name
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -
Overview
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. -
Synonyms
PPARGC1A;peroxisome proliferator-activated receptor gamma, coactivator 1 alpha;peroxisome proliferative activated receptor, gamma, coactivator 1 , peroxisome proliferative activated receptor, gamma, coactivator 1, alpha , PPARGC1;peroxisome proliferator-activated receptor gamma coactivator 1-alpha;PGC1;PGC1A;LEM6;Ligand effect modulator 6;Peroxisome proliferative activated receptor gamma coactivator 1 alpha;Peroxisome proliferative activated receptor gamma coactivator 1;Peroxisome proliferator activated receptor gamma coactivator 1 alpha;PGC 1 (alpha);PGC 1 alpha;PGC 1v;PGC-1-alpha;PGC1(alpha);PGC1v;PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6;PPAR gamma coactivator 1 alpha;PPAR gamma coactivator 1;PPAR gamma coactivator 1-alpha;PPAR gamma coactivator variant form;PPAR-gamma coactivator 1-alpha;PPARGC 1 alpha;PPARGC-1-alpha;PPARGC1;PRGC1_HUMAN;OTTHUMP00000123372;ligand effect modulator-6;PGC-1v;PGC-1(alpha)
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPARGC1A-729H |
Recombinant Human PPARGC1A Protein, His-tagged
|
E.coli | Human | His | Ser573~Asn767 | |
| PPARGC1A-2611H | Recombinant Human PPARGC1A Protein, His-tagged | E.coli | Human | His | Glu350-Arg798 | |
| PPARGC1A-13163M | Recombinant Mouse PPARGC1A Protein | Mammalian Cells | Mouse | His |
|
|
| PPARGC1A-4594R | Recombinant Rat Ppargc1a protein, His-tagged | E.coli | Rat | His | Ser588~Ser773 |
|
| PPARGC1A-8291H | Recombinant Human PPARGC1A protein, GST-tagged | Wheat Germ | Human | GST | 689-798 a.a. |
|
| Ppargc1a-8492M | Recombinant Mouse Ppargc1a protein, His-tagged | E.coli | Mouse | His | 577-766 a.a. |
|
| PPARgC1a-1248R | Recombinant Rat PPARgC1a protein, His-tagged | E.coli | Rat | His | Glu348~Arg796 |
|
| Ppargc1a-1962M | Recombinant Mouse Ppargc1a Protein, His-tagged | E.coli | Mouse | His | Glu349-Arg797 |
|
| PPARGC1A-32H | Recombinant Human PPARG coactivator 1 alpha Protein, His tagged | E.coli | Human | His | 511-End |
|
| PPARGC1A-5343H | Recombinant Human PPARGC1A protein | E.coli | Human | Non | 1-798a.a. |
|
| PPARGC1A-6970M | Recombinant Mouse PPARGC1A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
|
|
| PPARGC1A-6970M-B | Recombinant Mouse PPARGC1A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| PPARGC1A-7129H | Recombinant Human PPARGC1A protein(1-798aa), His-tagged | E.coli | Human | His | 1-798aa |
|
Involved Pathway
PPARGC1A involved in several pathways and played different roles in them. We selected most pathways PPARGC1A participated on our site, such as AMPK signaling pathway,Insulin signaling pathway,Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARGC1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | PRKAA2,PRKCE,RPS6KA3A,PRKCBB,CREB1A,SLC27A3,GYS1,MAPK8B,PPP1R3A,SLC27A5 |
| Adipocytokine signaling pathway | POMCA,TNFRSF1B,RXRAA,ADIPOR1,AKT2L,ACSL1,CAMKK1,RXRGB,G6PC3,CPT1B |
| AMPK signaling pathway | CREB3L3,Scd1,AKT2,CAB39,PFKM,HNF4A,CREB3L4,PRKAB1,GYS2,PFKP |
| Insulin signaling pathway | SOCS1A,CALM1,GYS1,PRKAA2,MKNK2A,PPP1CBL,KRAS,PTPRFB,FOXO1A,PPP1CA |
| Huntingtons disease | DNAH11,VDAC1,ATP5O,TBP,ITPR1,DNAI2,POLR2J3,NDUFB2,NDUFB10,COX7B |
Protein Function
PPARGC1A has several biochemical functions, for example, DNA binding,RNA binding,RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARGC1A itself. We selected most functions PPARGC1A had, and list some proteins which have the same functions with PPARGC1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleic acid binding | GTF3AA,ZFP410,CPSF1,SSX5,SREK1IP1,ZFP422,ZFY1,GLIS2,RBMS2B,KLF7B |
| estrogen receptor binding | PADI2,NSD1,CNOT1,ISL1,TRIP4,FUS,LEF1,NKX3,XBP1,CTNNB1 |
| sequence-specific DNA binding | ZFP42,ZNF205,NKX2,ARXA,ZSCAN12,LHX4,CAMTA1,SMAD3A,SP1,ZNF232 |
| transcription factor binding | HDAC8,PIAS1,ZEB1,MED12,FHL2,INSIG2,HDAC7,SMAD2,RBFOX2,PPARG |
| transcription coactivator activity | PER2,MED20,ASXL1,CDK7,WWC1,SMARCE1,KAT2A,NFKB2,ATXN7L3,EP300 |
| DNA binding | TLX3B,SP140L,NKX2.9,HMGN1,RAG1,HOXC4A,ZNF444,POT1A,HMX1,SP140 |
| alpha-tubulin binding | SERPINB1A,HDAC6,DDL-2,PROL1,ARL8B,B4GALT1,WASH1,TRPV4,FAM110C,ARL4C |
| RNA polymerase II transcription cofactor activity | MED17,MED21,MED13B,MED19A,FOXH1,NKX2-5,MED13L,PPRC1,MED7,MED19 |
| chromatin DNA binding | RELA,MYOG,THRB,THRA,BCL6,VAX1,NEUROG3,FOXO3,RUVBL2,ATOH1 |
Interacting Protein
PPARGC1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARGC1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARGC1A.
Sirt1;Irf4;Lrpprc;LRPPRC;IQGAP1;EP300;SIRT1;NR1I2
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