PPA2
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Official Full Name
pyrophosphatase (inorganic) 2 -
Overview
The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. -
Synonyms
PPA2;pyrophosphatase (inorganic) 2;inorganic pyrophosphatase 2, mitochondrial;FLJ20459;HSPC124;PPase2;Pyrophosphatase SID6 306;PPase 2;OTTHUMP00000158985;OTTHUMP00000158986;OTTHUMP00000218513;OTTHUMP00000218514;pyrophosphatase SID6-306;pyrophosphate phospho-hydrolase 2;SID6-306
Recombinant Proteins
- Yeast
- Zebrafish
- Mouse
- Human
- Schizosaccharomyces pombe (strain 972)
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ppa2-1868Y | Recombinant Yeast ppa2, GST-tagged | E.coli | Yeast | GST | 123-322 | |
| PPA2-11689Z | Recombinant Zebrafish PPA2 | Mammalian Cells | Zebrafish | His |
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| PPA2-13153M | Recombinant Mouse PPA2 Protein | Mammalian Cells | Mouse | His |
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| PPA2-242H | Recombinant Human PPA2 Protein, His-tagged | E.coli | Human | His |
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| PPA2-2994HCL | Recombinant Human PPA2 293 Cell Lysate | HEK293 | Human | Non |
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| Ppa2-5028M | Recombinant Mouse Ppa2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| PPA2-6962M | Recombinant Mouse PPA2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PPA2-6962M-B | Recombinant Mouse PPA2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ppa2-7543S | Recombinant Schizosaccharomyces pombe (strain 972) ppa2 protein, His&Myc-tagged | E.coli | Schizosaccharomyces pombe (strain 972) | His&Myc | 1-322a.a. |
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Involved Pathway
PPA2 involved in several pathways and played different roles in them. We selected most pathways PPA2 participated on our site, such as Oxidative phosphorylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | ATP6V1A,UQCRQ,NDUFB6,ATP5L,NDUFA8,NDUFS8B,ATP6V1BA,ATP5H,NDUFA6,ATP5G1 |
Protein Function
PPA2 has several biochemical functions, for example, inorganic diphosphatase activity,magnesium ion binding,protein serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPA2 itself. We selected most functions PPA2 had, and list some proteins which have the same functions with PPA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| magnesium ion binding | ATP9A,OPA1,NUDT3,RPS6KA3,ENO4,IDH2,NCS1,THTPA,ENO1,NT5C3B |
| inorganic diphosphatase activity | PRUNE,PPA1,PPA1B,PPA1A,LHPP |
| protein serine/threonine phosphatase activity | DUSP23B,CTDNEP1,PDP2,UBLCP1,CDC14B,PPP1R3C,PPP6C,CDC14A,PPM1K,PPP4C |
Interacting Protein
PPA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPA2.
HTT;15-deoxy-delta(12,14;ZWINT;MYC;COMT;SIRT4
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References
- Gomez-Garcia, MR; Serrano, A; et al. Expression studies of two paralogous ppa genes encoding distinct Family I pyrophosphatases in marine unicellular cyanobacteria reveal inactivation of the typical cyanobacterial gene. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 295:890-897(2002).
- Rojas-Beltran, JA; Dubois, F; et al. Identification of cystosolic Mg2+-dependent soluble inorganic pyrophosphatases in potato and phylogenetic analysis. PLANT MOLECULAR BIOLOGY 39:449-461(1999).
