POR
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Official Full Name
P450 (cytochrome) oxidoreductase -
Overview
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008] -
Synonyms
POR;P450 (cytochrome) oxidoreductase;CPR;CYPOR;P450R;NADPH--cytochrome P450 reductase;NADPH-dependent cytochrome P450 reductase
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Chicken
- Rat
- Insect Cells
- Mammalian Cells
- E.coli
- Sf9 Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&T7
- His&Fc&Avi
- N-mSUMO & C-His
- His&Myc
- Myc&DDK
- Flag
Involved Pathway
POR involved in several pathways and played different roles in them. We selected most pathways POR participated on our site, such as bile acid biosynthesis, neutral pathway,cytochrome P450,melatonin degradation I, which may be useful for your reference. Also, other proteins which involved in the same pathway with POR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cytochrome P450 | CYP2A7,CYP20A1,CYP4Z1,CYB5R3,CYB5A,CYP4V2,CYB5B,CYP2W1,CYP4F12 |
| bile acid biosynthesis, neutral pathway | ACAA2 |
Protein Function
POR has several biochemical functions, for example, FMN binding,NADP binding,NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POR itself. We selected most functions POR had, and list some proteins which have the same functions with POR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| FMN binding | TYW1,CREG2,TYW1B,HAO2,MTRR,NOS2B,NDOR1,NOS2A,CREG1,DHODH |
| nitric oxide dioxygenase activity | CYGB |
| enzyme binding | APOA1,ARPC4,PARK7,UGT1A6A,PARP1,Slc4a2,PRKCH,TUT1,Ar,DHCR24 |
| hydrolase activity | EIF4A1B,PPP3CB,GLS,EAR2,FAAH2A,PRSS28,FIGNL1,DPEP3,PTPN20,SHHB |
| iron ion binding | HBZ,BRSK2,CYP2X9,CYP20A1,HBM,HBQ1,CYP2AA8,ALOX5,HBA1,CYP2R1 |
| protein binding | MTIF3,PTPRB,KAT8,UBE2IB,SPSB4,ANKMY2,PMP22,TEKT4,SCIMP,PRSS2 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | CYP11A1,MICAL1,CYP11B1,CYP11C1,COQ6,CYP4F18,CYP4F2,CYP11B2,MICAL2,MTRR |
| NADP binding | H6PD,CRYM,FMO5,FMO3,NOX1,NOS1,MTHFR,DHFRL1,GSR,ASPDH |
| electron carrier activity | UGDH,ASPH,ACOXL,AOX4,TXNRD3,AOC2,IVD,GSR,NDUFS6,CYCSB |
Interacting Protein
POR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POR here. Most of them are supplied by our site. Hope this information will be useful for your research of POR.
PGRMC1;CYP2C2;Hmox1;XRCC6;STAT1;RABEPK
Resources
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References
- Gonzales, I; Miranda, JJ; et al. Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study. TROPICAL MEDICINE & INTERNATIONAL HEALTH 20:546-552(2015).
- Sancak, A; Favrot, C; et al. Antibody titres against canine papillomavirus 1 peak around clinical regression in naturally occurring oral papillomatosis. VETERINARY DERMATOLOGY 26:57-+(2015).
