PON3
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Official Full Name
paraoxonase 3 -
Overview
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008] -
Synonyms
PON3;paraoxonase 3;serum paraoxonase/lactonase 3;paraoxanase-3;arylesterase 3
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rat
- Mammalian Cell
- Insect Cells
- E.coli
- Insect Cell
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PON3-13123M | Recombinant Mouse PON3 Protein | Mammalian Cell | Mouse | His |
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| PON3-27H | Recombinant Full Length Human PON3 protein, His-tagged | Insect Cells | Human | His | Full L. 1-354 aa |
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| PON3-3018Z | Recombinant Zebrafish PON3 | Mammalian Cell | Zebrafish | His |
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| PON3-4579R | Recombinant Rat PON3 Protein | Mammalian Cell | Rat | His |
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| PON3-594H | Active Recombinant Human PON3 protein(Gly2~Leu354), His-tagged | E.coli | Human | His | Gly2~Leu354 |
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| PON3-467HCL | Recombinant Human PON3 cell lysate | Insect Cell | Human | Non |
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| PON3-4239R | Recombinant Rat PON3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PON3-4239R-B | Recombinant Rat PON3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PON3-4954H | Recombinant Human PON3 Protein (Leu22-Leu354), N-His tagged | E.coli | Human | His | Leu22-Leu354 |
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| PON3-6941M | Recombinant Mouse PON3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PON3-6941M-B | Recombinant Mouse PON3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PON3 involved in several pathways and played different roles in them. We selected most pathways PON3 participated on our site, such as Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PON3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ST6GALNAC6,CYP2J5,DNMT3B,MAT1A,PNMT,DGKE,ALDH6A1,ATP6V1H,SDHA,GPI1 |
Protein Function
PON3 has several biochemical functions, for example, 3,4-dihydrocoumarin hydrolase activity,aryldialkylphosphatase activity,arylesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PON3 itself. We selected most functions PON3 had, and list some proteins which have the same functions with PON3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | HNF1B,BCL2A1A,ACTN2,VIL1,BIRC5,MLL1,BCL2L2,ATF3,CD2,ACTN3 |
| 3,4-dihydrocoumarin hydrolase activity | Aadacl3,NOTUM1A,CEL.1,ABHD2B,DAGLB,CELL,Cel,LIPK,LIPM,PNPLA7 |
| metal ion binding | ZNF865,ISL1L,AGMAT,ASGR1,DMRTA2,PRICKLE1A,CDK15,PHC2A,ASAP2A,MBTD1 |
| aryldialkylphosphatase activity | PON1 |
| arylesterase activity | Car2,PON1,PON2,APMAP,CA2,CAR1,CA1,C20orf3 |
Interacting Protein
PON3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PON3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PON3.
q9wmx2-pro_0000037550;d-mannose
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References
- Rull, A; Garcia, R; et al. Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease. ATHEROSCLEROSIS 220:545-551(2012).
- Garcia-Heredia, A; Marsillach, J; et al. Serum paraoxonase-3 concentration is associated with the severity of hepatic impairment in patients with chronic liver disease. CLINICAL BIOCHEMISTRY 44:1320-1324(2011).
