POLR2B
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Official Full Name
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -
Overview
This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA. -
Synonyms
POLR2B;polymerase (RNA) II (DNA directed) polypeptide B, 140kDa;polymerase (RNA) II (DNA directed) polypeptide B (140kD);DNA-directed RNA polymerase II subunit RPB2;RPB2;RNA polymerase II subunit 2;RNA polymerase II subunit B2;DNA-directed RNA poly
Recombinant Proteins
- Mouse
- Chicken
- Zebrafish
- Rhesus macaque
- Mammalian Cells
- HEK293
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POLR2B-13092M | Recombinant Mouse POLR2B Protein | Mammalian Cells | Mouse | His |
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| POLR2B-1588C | Recombinant Chicken POLR2B | Mammalian Cells | Chicken | His |
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| POLR2B-3048Z | Recombinant Zebrafish POLR2B | Mammalian Cells | Zebrafish | His |
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| POLR2B-3513R | Recombinant Rhesus monkey POLR2B Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| POLR2B-3331R | Recombinant Rhesus Macaque POLR2B Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| POLR2B-3331R-B | Recombinant Rhesus Macaque POLR2B Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| POLR2B-6921M | Recombinant Mouse POLR2B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| POLR2B-6921M-B | Recombinant Mouse POLR2B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
POLR2B involved in several pathways and played different roles in them. We selected most pathways POLR2B participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Huntingtons disease | COX6A2,UQCRQ,BDNF,GRIN1,COX4I1,DCTN2,SIN3A,ATP5E,NDUFB7,DNALI1 |
| Pyrimidine metabolism | NT5C1AA,POLR2J,ENTPD4,TK1,POLR2L,NT5C2B,TXNRD2,ITPA,UCK2A,POLE |
| Purine metabolism | PKM,CANT1,NME2B.2,NT5C2A,RRM2,ADSSL,PDE4A,PDE3A,DGUOK,ITPA |
| Metabolic pathways | CYP4A14,GALNT6,NDUFB11,NDUFB2,MBOAT1,AGK,GALT,IMPAD1,POLR3H,ALP3 |
| Epstein-Barr virus infection | TYK2,TRAF2,HLA-DRB5,POLR2H,ITGAL,MAPK8,EIF2AK4,TRP53,POLR2D,HDAC4 |
| RNA polymerase | POLR1D,POLR2K,POLR2EB,POLR2C,POLR2L,POLR3A,POLR2D,POLR2GL,POLR3K,POLR2J |
Protein Function
POLR2B has several biochemical functions, for example, DNA binding,DNA-directed RNA polymerase activity,contributes_to RNA polymerase II activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2B itself. We selected most functions POLR2B had, and list some proteins which have the same functions with POLR2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF43,HER8.2,MCM3L,HOXA13,ZNF654,ISL2,RAD51L3,ATOH7,VPS72,SOS1 |
| contributes_to RNA polymerase II activity | POLR2EB,POLR2F,POLR2C,POLR2J3,POLR2L,POLR2J2,POLR2E,POLR2K,POLR2A,POLR2J |
| metal ion binding | WT1A,TRIM35-39,GLIS2B,S100S,BTR06,ALKBH5,HDAC7A,ZNF80,ERI3,ACLYA |
| poly(A) RNA binding | HSPD1,HIST1H4J,RPS21,TTC6,RPL30,DARS,HNRNPM,EXOSC10,MRPS7,DDX49 |
| ribonucleoside binding | POLR3B |
| DNA-directed RNA polymerase activity | POLR2E,POLR2M,POLR3F,POLR3C,POLR2GL,POLR3B,POLR1C,POLR2I,POLR3A,CD3EAP |
| chromatin binding | CREB3,TOX,GLI3,CBX1,TTC5,ATOH1A,SIRT2,PBX2,TADA2A,UBTF |
| nucleotidyltransferase activity | OASL2,PAPSS1,GMPPA,PRIM2,CMASA,GMPPAA,CTU2,CMASB,GKUP,POLR3B |
| transferase activity | TRIO,GXYLT2,DGAT1B,PGGT1B,ZDHHC23B,MOB1BA,ZDHHC20A,TRIOA,LMTK3,UGT1B4 |
Interacting Protein
POLR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2B.
Nphp4;Ywhae;Tfcp2l1;Ezh2;Nanog;Tada2a;Kat2a;Aire
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References
- Sun, YY; Li, SS; et al. TNFRSF10A-LOC389641 rs13278062 But Not REST-C4orf14-POLR2B-IGFBP7 rs1713985 Was Found Associated With Age-Related Macular Degeneration in a Chinese Population. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:8199-8203(2013).
- Zhou, J; Wang, D; et al. RAD51 gene is associated with advanced age-related macular degeneration in Chinese population. CLINICAL BIOCHEMISTRY 46:1689-1693(2013).
