POLD3
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Official Full Name
polymerase (DNA-directed), delta 3, accessory subunit -
Overview
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3 to;5 exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in;regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor;proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. -
Synonyms
POLD3;polymerase (DNA-directed), delta 3, accessory subunit;DNA polymerase delta subunit 3;KIAA0039;P66;P68;DNA polymerase delta subunit p66;MGC119642;MGC119643
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POLD3-1429C | Recombinant Chicken POLD3 | Mammalian Cells | Chicken | His |
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| POLD3-3842Z | Recombinant Zebrafish POLD3 | Mammalian Cells | Zebrafish | His |
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| POLD3-1389HCL | Recombinant Human POLD3 cell lysate | Human | Non |
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Involved Pathway
POLD3 involved in several pathways and played different roles in them. We selected most pathways POLD3 participated on our site, such as Base Excision Repair,Cell Cycle,Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | BRE,GADD45BA,BORA,CP110,VRK1,CUL1B,CDCA8,PANE1,CLASP1,SPO11 |
| Cell Cycle, Mitotic | SMC4,CDKN2D,LIN9,MLF1IP,CDK7,NEK7,TMPO,VRK2,LIN52,CDK11A |
| Base excision repair | HMGB1,HMGB1A,MBD4,UNGA,TDG.1,PARP4,PARP1,UNG,PCNA,POLE |
| DNA Repair | TCEA1,TFPT,PPP4R2,UIMC1,KIAA1530,MCRS1,BRE,TIPIN,COPS8,DTL |
| DNA Damage Bypass | USP43A,DTL,MAD2L2,KIAA0101,POLI,USP10,DDB1,ZBTB32,SPRTN,USP43 |
| DNA Double-Strand Break Repair | GEN1,PARP2,RNF168,TOPBP1,KIAA0146,PAXIP1,TP53BP1,RBBP8,THRSP,UIMC1 |
| Chromosome Maintenance | POT1,APITD1,CENPN,TERF2IP,MIS18BP1,TERF1,OIP5,RBBP4,ACD,POT1A |
Protein Function
POLD3 has several biochemical functions, for example, DNA-directed DNA polymerase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLD3 itself. We selected most functions POLD3 had, and list some proteins which have the same functions with POLD3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ERCC5,CXXC5,TEKT3,ARHGEF2,PTPN23,DOK4,CCDC130,HLCS,SPANXD,VCP |
| DNA-directed DNA polymerase activity | POLA2,POLE4,PAPD7,POLM,POLG2,POLE,POLD1,POLI,POLD2,POLB |
Interacting Protein
POLD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLD3.
POLD1;PCNA;POLD2;pcn1;PCNA;ssdna_dtdg
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References
- Bursomanno, S; Beli, P; et al. Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells. DNA REPAIR 25:84-96(2015).
- Lingeman, RG; Hickey, RJ; et al. Expression of a novel peptide derived from PCNA damages DNA and reverses cisplatin resistance. CANCER CHEMOTHERAPY AND PHARMACOLOGY 74:981-993(2014).
