POF1B
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Official Full Name
premature ovarian failure, 1B -
Overview
Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This genes expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined. -
Synonyms
POF1B;premature ovarian failure, 1B;protein POF1B;FLJ22792;POF;premature ovarian failure protein 1B;POF2B
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POF1B-1824H | Recombinant Human POF1B, GST-tagged | E.coli | Human | GST | C-term-350aa | |
| POF1B-13059M | Recombinant Mouse POF1B Protein | Mammalian Cells | Mouse | His |
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| POF1B-2407H | Recombinant Human POF1B Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| POF1B-2725H | Recombinant Human POF1B Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Pof1b-4978M | Recombinant Mouse Pof1b Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| POF1B-6901M | Recombinant Mouse POF1B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| POF1B-6901M-B | Recombinant Mouse POF1B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
POF1B involved in several pathways and played different roles in them. We selected most pathways POF1B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with POF1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
POF1B has several biochemical functions, for example, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POF1B itself. We selected most functions POF1B had, and list some proteins which have the same functions with POF1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | SHANK3,PFN1,SPIRE1A,DST,ACTN3,MYH15,PAWR,WAS,FMN2,EPS8L2 |
Interacting Protein
POF1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POF1B here. Most of them are supplied by our site. Hope this information will be useful for your research of POF1B.
ESR1;GABARAPL1
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References
- Crespi, A; Bertoni, A; et al. POF1B Localizes to Desmosomes and Regulates Cell Adhesion in Human Intestinal and Keratinocyte Cell Lines. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:192-201(2015).
- Butts, SF; Sammel, MD; et al. Cigarettes, genetic background, and menopausal timing: the presence of single nucleotide polymorphisms in cytochrome P450 genes is associated with increased risk of natural menopause in European-American smokers. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 21:694-701(2014).
