PNPT1
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Official Full Name
polyribonucleotide nucleotidyltransferase 1 -
Overview
PNPT1 is a subunit of the exosome complex, which is involved in 3-prime-to-5-prime exoribonuclease activity for RNA;processing and degradation (Raijmakers et al., 2002 (PubMed 12419256)). -
Synonyms
PNPT1;polyribonucleotide nucleotidyltransferase 1;polyribonucleotide nucleotidyltransferase 1, mitochondrial;3 5 RNA exonuclease;old 35;OLD35;PNPase;polynucleotide phosphorylase;PNPase 1;Polynucleotide phosphorylase like protein;PNPase old-35;3-5 RNA exonuclease OLD35;polynucleotide phosphorylase 1;polynucleotide phosphorylase-like protein;old-35
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PNPT1-1821H | Recombinant Human PNPT1, GST-tagged | E.coli | Human | GST | 427-783aa | |
| PNPT1-13049M | Recombinant Mouse PNPT1 Protein | Mammalian Cells | Mouse | His |
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| PNPT1-8099Z | Recombinant Zebrafish PNPT1 | Mammalian Cells | Zebrafish | His |
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| PNPT1-1386HCL | Recombinant Human PNPT1 cell lysate | Human | Non |
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| PNPT1-6894M | Recombinant Mouse PNPT1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PNPT1-6894M-B | Recombinant Mouse PNPT1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PNPT1 involved in several pathways and played different roles in them. We selected most pathways PNPT1 participated on our site, such as Purine metabolism,Pyrimidine metabolism,RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | GUK1B,ENTPD3,POLE2,NT5C1B,PDE8A,POLR2F,PRPS1A,ENPP1,PNP5A,GUCY1B3 |
| Pyrimidine metabolism | CANT1,POLR2C,NME2A,POLR2E,TXNRD3,POLR2B,UPP1,UCKL1,CMPK,udp |
| RNA degradation | PFKMB,CNOT1,LSM7,ENO1,LSM5,DCPS,BTG3,PATL1,GM5506,LSM8 |
Protein Function
PNPT1 has several biochemical functions, for example, 3-5-exoribonuclease activity,miRNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPT1 itself. We selected most functions PNPT1 had, and list some proteins which have the same functions with PNPT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| miRNA binding | AGO3,TARBP2,DICER1,EIF2C3,AGO1,TRIM71,AGO2,POU5F1,MEF2C,LIN28A |
| poly(G) binding | HNRNPDL,HNRPDL,PATL2,PATL1 |
| poly(A) RNA binding | UBE2L3,SF3B14,PWP2,TRIM28,AGO3,DUSP14,ZFC3H1,SORBS2,SRPR,RBM4 |
| poly(U) RNA binding | HNRNPH1,RBM11,HNRNPC,PATL1,KHDRBS2,KHDRBS1,MSI1,PABPC4,DIS3L2,KHDC1A |
| 3-5-exoribonuclease activity | SMFN,EXOSC5,C16orf57,DIS3L2,CNOT7,ISG20,REXO2,ERI3,TOE1,EXOSC7 |
| protein binding | ZFP64,P4HA2,TMEM31,C11orf49,MTDH,CETN2,WWP1,PDE4C,PRDM10,LMAN1 |
Interacting Protein
PNPT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPT1.
MCC;TRAF6;HSPB1;LTN1;ICT1
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