PML
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Official Full Name
PML promyelocytic leukemia -
Synonyms
PML;promyelocytic leukemia;protein PML;MYL;RNF71;TRIM19;RING finger protein 71;promyelocytic leukemia protein;tripartite motif protein TRIM19;probable transcription factor PML;promyelocytic leukemia, inducer of;tripartite motif-containing protein 19;PP8675
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- Insect Cells
- His
- DDK
- Myc
- GST
- Non
- Flag
- Avi
- Fc
Involved Pathway
PML involved in several pathways and played different roles in them. We selected most pathways PML participated on our site, such as Ubiquitin mediated proteolysis,Endocytosis,Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with PML were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | C3A.2,EP300,IFNG1-2,OAS3,ARNTL1B,SFRS9,PVRL1,TTC6,HLA-F,EIF2AK4 |
| Influenza A | IFNA16,DNAJB1,NFKBIA,STAT1,PIK3CA,MAP2K2,HLA-DRB1,IL8L2,MAP2K3,MAP2K7 |
| Ubiquitin mediated proteolysis | UBE2L3A,FBXW11A,MAP3K1,VHL,UBE3B,UBE2Q2,CDH1-A,UBE2Z,SYVN1,UBR5 |
| Acute myeloid leukemia | PIM2,STAT5B,SFPI1,TCF7,PIK3R1,KIT,SPI1,STAT5A,IKBKG,ZBTB16 |
| Endocytosis | ARPC3,RAB4A,CXCR2,CYTH4,MVB12BB,KITA,FLT1,EHD2,ARPC4,RAB11FIP4 |
| Transcriptional misregulation in cancer | RXRG,REL,ETV4,PLAT,MLLT3,PLAU,CDK14,RUNX1,IGFBP3,NFKBIZ |
| Pathways in cancer | SOS1,FGF16,HIF1A,TPM3,LAMB4,FZD3,GRB2,FAS,LPAR6,FGF7 |
Protein Function
PML has several biochemical functions, for example, DNA binding,SMAD binding,SUMO binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PML itself. We selected most functions PML had, and list some proteins which have the same functions with PML. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | SQSTM1,OTUB1,WASH,TNFRSF1B,NKD2,YWHAZ,MUL1,UBE2T,TRIB1,CCT2 |
| zinc ion binding | DNPEP,RARAB,LHX8A,RBM14B,HHIP,TP53I3,ZDHHC22,PEX10,CCNB1IP1,RNF144A |
| transcription coactivator activity | TADA3,JUNBA,TAF10,GATA4,TAF11,TAF7L,MED17,TFDP1,ATXN7L3,YY1 |
| SUMO binding | HERC2,USP25,TDG,TOLLIP,CBX4,RPS3,USPL1 |
| SMAD binding | PURA,HIPK2,ACVR1,CTNNB1,CREBBP,ACVR1B,AXIN1,SOD3,FLNA,BMP2 |
| protein heterodimerization activity | HMG20A,DRAP1,HOMER1,GCA,PDSS1,TAF9,TGFB3,ADD2,IL12A,UGT1A1 |
| DNA binding | MGAA,ZFAT,E2F6,ASCL3,PAX6A,HIST1H4B,SCRT1,HOXB8A,LBR,CDT1 |
| protein homodimerization activity | GSTM7,GABPB2,GOLGA5,DMRTC1C2,NAGA,FLRT3,FLT3LG,MID1,SEPT12,GHR |
| protein binding | ATXN7,PIAS1,INTS12,ENOX2,DAG1,HSPA5,INTS5,JUP,HOXA5,ZNF329 |
Interacting Protein
PML has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PML here. Most of them are supplied by our site. Hope this information will be useful for your research of PML.
DAXX;KLHL20;TP53;SUMO1
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References
- DeHart, CJ; Perlman, DH; et al. Impact of the Adenoviral E4 Orf3 Protein on the Activity and Posttranslational Modification of p53. JOURNAL OF VIROLOGY 89:3209-3220(2015).
- Villar, LM; Costa-Frossard, L; et al. Lipid-Specific Immunoglobulin M Bands in Cerebrospinal Fluid Are Associated with a Reduced Risk of Developing Progressive Multifocal Leukoencephalopathy during Treatment with Natalizumab. ANNALS OF NEUROLOGY 77:447-457(2015).
