PLK3

  • Official Full Name

    polo-like kinase 3

  • Overview

    Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis. [provided by RefSeq, Jul 2008]

  • Synonyms

    PLK3;polo-like kinase 3;CNK;FNK;PRK;serine/threonine-protein kinase PLK3;PLK-3;FGF-inducible kinase;cytokine-inducible kinase;proliferation-related kinase;cytokine-inducible serine/threonine-protein kinase

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • Insect Cells
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi&Fc&His
Cat.# Product name Source (Host) Species Tag Protein Length Price
PLK3-1069 Active Recombinant Human PLK3 protein, GST-tagged Insect Cells Human GST 57-340
PLK3-1069H Active Recombinant Human PLK3, GST-tagged Sf9 Cells Human GST 57-340
PLK3-11456Z Recombinant Zebrafish PLK3 Mammalian Cells Zebrafish His
PLK3-31032TH Recombinant Human PLK3, His-tagged Human His 58-339 a.a.
PLK3-4527R Recombinant Rat PLK3 Protein Mammalian Cells Rat His
PLK3-566H Recombinant Human Polo-like Kinase 3 (Drosophila), His-tagged Sf9 Cells Human His 58-339 a.a.
PLK3-3103HCL Recombinant Human PLK3 293 Cell Lysate HEK293 Human Non
PLK3-4187R Recombinant Rat PLK3 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
PLK3-4187R-B Recombinant Rat PLK3 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    PLK3 involved in several pathways and played different roles in them. We selected most pathways PLK3 participated on our site, such as Direct p53 effectors,FoxO signaling pathway,Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Polo-like kinase signaling events in the cell cycle PLK2
    Direct p53 effectors BCL2L14,CTSD,AIFM2,FDXR,DUSP5,ZNF385A,PCBP4,BNIP3L,PRDM1,DGCR8
    Tuberculosis IFNA4,CD14,CLEC7A,HLA-DQA1,HLA-DQB1,AKT1,Pla2r1,MYD88,IL12B,LAMP1
    Integrated Breast Cancer Pathway SELK,CCNB1IP1,C21orf7,MYT1,BACH1,AHR,ANXA1,LGALS13,USP16,USP38
    FoxO signaling pathway CCND1,FOXO6,PDPK1,GABARAPL1,BCL6A,MDM2,EP300,PRKAA1,PRKAB2,FASLG

    Protein Function

    PLK3 has several biochemical functions, for example, ATP binding,p53 binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLK3 itself. We selected most functions PLK3 had, and list some proteins which have the same functions with PLK3. You can find most of the proteins on our site.

    Function Related Protein
    p53 binding TRP63,NUAK1,ANKRD1,CDK5,MAPKAPK5,ZNF385B,RFWD3,SMYD2,ZMAT3,CDKN2AIP
    protein serine/threonine kinase activity STK10,CLK1,PRKCBA,PRKCQ,FASTK,NEK6,STK35L,CDK15,MKNK2,PRKACBB
    protein binding DDX18,APBA2,NOL9,THAP11,PRUNE,ZFP57,CDCA8,SCNM1,BCL11B,ZNF143
    ATP binding NMRK2,GC2,STK32C,RPS6KA1,ORC4,PAPSS2,C9orf96,CDC34,BCS1L,ATP2A1L

    Interacting Protein

    PLK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLK3.

    VRK1;PRNP;POU2F1;atp

    Resources

    Research Area

    Intracellular Kinases in the Akt Pathway
    Polo-like Kinases
    G2/M (DNA Damage) Checkpoints

    References

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