PLEKHA2
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Official Full Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 [ Homo -
Synonyms
PLEKHA2;pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2;14336;ENSG00000169499;TAPP2;8p11.22;FLJ25921;pleckstrin homology domain-containing family A member 2;pleckstrin homology domain-containing family A member 2;TAPP-2;tandem PH Domain containing protein-2;tandem PH domain-containing protein 2;PH domain-containing family A member 2;pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
Recombinant Proteins
- Mouse
- Chicken
- Human
- Mammalian Cells
- HEK293
- His
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PLEKHA2-12942M | Recombinant Mouse PLEKHA2 Protein | Mammalian Cells | Mouse | His |
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| PLEKHA2-6264C | Recombinant Chicken PLEKHA2 | Mammalian Cells | Chicken | His |
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| PLEKHA2-2096H | Recombinant Human PLEKHA2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| PLEKHA2-2107H | Recombinant Human PLEKHA2 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| Plekha2-4925M | Recombinant Mouse Plekha2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| PLEKHA2-6828M | Recombinant Mouse PLEKHA2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PLEKHA2-6828M-B | Recombinant Mouse PLEKHA2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PLEKHA2 involved in several pathways and played different roles in them. We selected most pathways PLEKHA2 participated on our site, such as B Cell Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLEKHA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | RAC2,RAF1,PIK3R3,ITPR2,PRKCB,PIK3CD,MAPK1,PLCG2,DUSP4,CD22 |
Protein Function
PLEKHA2 has several biochemical functions, for example, 1-phosphatidylinositol binding,PDZ domain binding,fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLEKHA2 itself. We selected most functions PLEKHA2 had, and list some proteins which have the same functions with PLEKHA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| laminin binding | ACHE,LRRC15,CTSS,THBS1,GPC1,LGALS3,NCL,ITGA7,ADAM9,RPSA |
| PDZ domain binding | DOCK4,PTENB,EXOC4,F11R,FZD7,LLGL2,ATP2B4,GNG12,ACCN3,PLEKHA1 |
| lipid binding | PRAM1,AP2M1,OSBPL11,FAM123C,RBP7B,DLC1,S1PR4,FABP6,BPIFB6,BPIFA5 |
| protein binding | TRAM1,CCDC137,PHOSPHO2-KLHL23,RNF20,STMN1,C6orf226,NF2,AKAP17A,INTS4,MVK |
| 1-phosphatidylinositol binding | EPB41,PICALMB,PLEKHA3,SNX10,ZFYVE16,CCDC167,SCARB1,SYT1,PICALM,SNAP91 |
| fibronectin binding | MMP13,FSTL3,VEGFA,ITGB1,LRRC15,ITGA4,CTGF,LACRT,SDC4,IGFBP5 |
Interacting Protein
PLEKHA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLEKHA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLEKHA2.
MPDZ;Hmga2
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References
- Qamra, R; Hubbard, SR; et al. Structural Basis for the Interaction of the Adaptor Protein Grb14 with Activated Ras. PLOS ONE 8:-(2013).
- Liu, JM; Fukuda, K; et al. Structural Basis of Phosphoinositide Binding to Kindlin-2 Protein Pleckstrin Homology Domain in Regulating Integrin Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 286:43334-43342(2011).
