PLD1
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Official Full Name
phospholipase D1, phosphatidylcholine-specific -
Overview
Phospholipase D1 catalyzes the hydrolysis of PC to produce phosphatidic acid and choline and is implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May also be involved in the regulation of perinuclear intravesicular membrane traffic. Phospholipase D2 may have a role in signal induced cytoskeletal regulation and/or endocytosis. The mechanisms that regulate phospholipase D2 are not known. -
Synonyms
Phospholipase D1 and Phospholipase D2;PLD1;phospholipase D1, phosphatidylcholine-specific;phospholipase D1;choline phosphatase 1;phosphatidylcholine-hydrolyzing phospholipase D1
Recombinant Proteins
- Human
- Rat
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PLD1-1770H | Recombinant Human PLD1, GST-tagged | E.coli | Human | GST | 725-1074aa | |
| PLD1-27923TH | Recombinant Human PLD1, GST-tagged | Wheat Germ | Human | GST |
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| PLD1-4509R | Recombinant Rat PLD1 Protein | Mammalian Cell | Rat | His |
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| PLD1-3123HCL | Recombinant Human PLD1 293 Cell Lysate | HEK293 | Human | Non |
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| PLD1-4169R | Recombinant Rat PLD1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PLD1-4169R-B | Recombinant Rat PLD1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PLD1-4932H | Recombinant Human PLD1 Protein (Thr725-Thr1074), N-His tagged | E.coli | Human | His | Thr725-Thr1074 |
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Involved Pathway
PLD1 involved in several pathways and played different roles in them. We selected most pathways PLD1 participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Choline metabolism in cancer | AKT2,CHKA,EGF,SLC44A1,PDPK1,SLC22A2,SLC44A2,PIK3R2,PIK3R3,MAPK9 |
| GnRH signaling pathway | CALM1,PLCB1,GNRH1,CACNA1SA,PLD1A,MAP3K3,GRB2,GNRHR1,Adcy4,CALM2A |
| Fc gamma R-mediated phagocytosis | DOCK2,CFL1,RPS6KB2,WASF1,PIK3R5,FCGR3A,PRKCD,WASF2,LIMK2,RPS6KB1 |
| Pathways in cancer | SUFU,Casp3,ITGA6,NFKB1,WNT4,FLT3LG,STAT1,BIRC2,GNB1,IKBKB |
| Pancreatic cancer | MAPK8,TGFBR2,AKT1,RAF1,PIK3CB,PIK3R2,PIK3R3,TGFBR1,RALGDS,BRCA2 |
| Glycerophospholipid metabolism | AGPAT6,EPT1,GPAT2,DGKE,GPD1A,MBOAT2B,AGPAT4,PISD,CDS1,PCYT1AA |
| Ether lipid metabolism | PLA2G12A,AGPS,PLA2G12B,EPT1,PLA2G6,CEPT1B,LPCAT4,GAL3ST1,PLA2G4AA,PLA2G4F |
| Sphingolipid signaling pathway | PPP2R1B,BID,S1PR5,RELA,SPTLC3,CERS4,PIK3CA,ROCK1,SMPD1,PLCB1 |
| cAMP signaling pathway | MAPK10,GNAI2,CAMK2D,PIK3R1,GLI1,PPP1CA,CAMK4,NPY,PRKACG,MAP2K1 |
Protein Function
PLD1 has several biochemical functions, for example, N-acylphosphatidylethanolamine-specific phospholipase D activity,phosphatidylinositol binding,phospholipase D activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLD1 itself. We selected most functions PLD1 had, and list some proteins which have the same functions with PLD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phospholipase D activity | GPLD1,PLD2,PLD4,PLD1A,PLD3,HMOX1 |
| protein binding | VPS37B,INADL,HER11,PPP3CA,PROX1,KRTAP10-8,RADIL,PTPN14,TRP63,CCDC135 |
| N-acylphosphatidylethanolamine-specific phospholipase D activity | NAPEPLD,PLD3,PLD2,PLD4 |
| phosphatidylinositol binding | ITPR2,NOXO1A,GRB7,ARHGAP33,MYO1E,TULP4,SNX12,HIP1R,NCF1,SNX33 |
Interacting Protein
PLD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLD1.
CFL1;PKN3;prkC;PLCG1;STXBP1
Resources
Research Area
Phospholipases, Small GTPases, and Other Molecules in the Akt PathwayFatty Acid Catabolism
Related Services
Related Products
References
- Huang, CF; Bruggeman, LA; et al. Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes. EXPERIMENTAL CELL RESEARCH 318:1075-1085(2012).
- Alexandrescu, S; Tatevian, N; et al. Morphoproteomics provides support for TGF-beta pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 5:503-511(2012).
