PLCD4
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Official Full Name
phospholipase C, delta 4 -
Overview
This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. -
Synonyms
PLCD4;phospholipase C, delta 4;1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4;1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase delta 4;hPLCD4;MGC12837;Phosphoinositide phospholipase C delta 4;Phospholipase C delta 4;PLC delta 4;PLC delta4;phosphoinositide phospholipase C-delta-4
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- His&T7
- Non
- His&SUMO
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PLCD4 involved in several pathways and played different roles in them. We selected most pathways PLCD4 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLCD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | KAT2A,ATP2A2,PIK3CG,ATP1A3,ATP1B2,ACTB,CCND1,FOXO1,ATP1A1,KRAS |
| Inositol phosphate metabolism | PLCD1A,PIK3C2B,INPP5D,INPP5KA,NUDT3B,PIP4K2A,MINPP1B,MTM1,MTMR1B,PLCD1 |
| Phosphatidylinositol signaling system | CALML5,CALM3,PIK3C2B,ITPKC,MTM1,MTMR1B,CALM2B,IMPAD1,PIK3CB,DGKAA |
| Calcium signaling pathway | PDE1B,PHKA2,PPP3CC,PRKCA,PLCG1,ERBB3A,PLCD3,P2RX3B,ITPKB,PLCD1 |
| Metabolic pathways | AGLA,ACSS1,GALNT10,INPP5A,ALDH4A1,ALOX15,PC,ADA,ITPA,GBA3 |
Protein Function
PLCD4 has several biochemical functions, for example, calcium ion binding,phosphatidylinositol phospholipase C activity,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLCD4 itself. We selected most functions PLCD4 had, and list some proteins which have the same functions with PLCD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PCDHGB4,LOC100686744,EFHB,RCN2,VLDLR,EFCAB4A,ITPR3,MYL6,SLIT1,RGN |
| signal transducer activity | PDCD1,OLFR10,NEK6,TAS2R107,LPAR2A,HTR1AB,TAAR4,TAAR10,CD24,TAS2R117 |
| phosphatidylinositol phospholipase C activity | CCKBR,EDNRA,PLCZ1,CCL5,PLCH2,BDKRB2,PLCB1,PLCB3,CASR,CHRM1 |
Interacting Protein
PLCD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLCD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLCD4.
TRIM39;IPO11
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References
- Mlcochova, P; Pelchen-Matthews, A; et al. Organization and regulation of intracellular plasma membrane-connected HIV-1 assembly compartments in macrophages. BMC BIOLOGY 11:-(2013).
- Yamaguchi, H; Yoshida, S; et al. Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase I alpha are required for invadopodia formation in human breast cancer cells. CANCER SCIENCE 101:1632-1638(2010).
