PLA2G4B
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Official Full Name
phospholipase A2, group IVB (cytosolic) -
Overview
This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. -
Synonyms
PLA2G4B;phospholipase A2, group IVB (cytosolic);cytosolic phospholipase A2 beta;cPLA2 beta;HsT16992;DKFZp686N12131;FLJ17693;FLJ42498;FLJ53173;OTTHUMP00000201605;OTTHUMP00000210673;Phospholipase A2 group IVB;cPLA2-beta
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PLA2G4B-1367HCL | Recombinant Human PLA2G4B cell lysate | Human | Non |
|
Involved Pathway
PLA2G4B involved in several pathways and played different roles in them. We selected most pathways PLA2G4B participated on our site, such as Acyl chain remodelling of PC,Acyl chain remodelling of PE,Acyl chain remodelling of PG, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fc epsilon RI signaling pathway | RAC1,RAC3,MAP2K4,VAV1,MAP2K7,MAPK13,PRKCA,PLA2G4C,FCER1A,LYN |
| Acyl chain remodelling of PS | PLA2G16 |
| Acyl chain remodelling of PE | PLA2G16,PNPLA8,PLBD1 |
| Arachidonic acid metabolism | CBR1,CYP2AD3,PTGES,FAAH2A,GPX3,CYP1A1,PTGIS,CYP2C45,GGTLC1,PTGS2A |
| Acyl chain remodelling of PC | PLBD1,PLB1,PNPLA8,PLA2G16 |
| Choline metabolism in cancer | KRAS,EGF,RPS6KB2,Pdgfa&Pdgfb,MAP2K2,PPAP2A,DGKQ,CHKA,WASF2,RALGDS |
| Ether lipid metabolism | CEPT1,PLD1,LPCAT1,PAFAH1B1A,PLB1,ENPP2,PAFAH1B1,TMEM86B,PPAP2A,PPAP2C |
Protein Function
PLA2G4B has several biochemical functions, for example, calcium ion binding,calcium-dependent phospholipase A2 activity,calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G4B itself. We selected most functions PLA2G4B had, and list some proteins which have the same functions with PLA2G4B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-dependent phospholipase A2 activity | PLA2G2A,PLA2G4F,PLA2G5,PLA2G3,PLA2G1B,PLA2G4A,PLA2G12A |
| calcium ion binding | ITIH1,EFHA1,MFGE8B,ANXA2B,PCDHA4,ITSN2A,CDH24,DGKG,PADI1,CHP2 |
| lysophospholipase activity | PLA2G4A,LYPLA1,PNPLA6,LYPLAL1,Cel,MGLL,PLB1,PNPLA7,PLA2G4F,PLA2G4AA |
| calcium-dependent phospholipid binding | ANXA2,SYTL3,ANXA2A,SYT9,RPH3A,PLA2G4A,ANXA3,PCLO,ANXA7,SYT1 |
Interacting Protein
PLA2G4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G4B here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G4B.
TFAP2A;uvrB;sdhA;pi3p
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