PLA2G1B
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Official Full Name
phospholipase A2, group IB (pancreas) -
Overview
Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known;varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2;enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to;venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine,;macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986;(PubMed 3028739)) . -
Synonyms
PLA2G1B;phospholipase A2, group IB (pancreas);PLA2, PLA2A, PPLA2;phospholipase A2;group IB phospholipase A2;phosphatidylcholine 2-acylhydrolase 1B;PLA2;PLA2A;PPLA2;MGC119834;MGC119835
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rat
- HEK293
- E.coli
- Mammalian cells
- Mammalian Cell
- Human Cell
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PLA2G1B involved in several pathways and played different roles in them. We selected most pathways PLA2G1B participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | PRKACG,PAK6,GNG8,CALML3,INS2,MRAS,SHC3,GNGT1,RAC3,RAB5B |
| Pancreatic secretion | PLA2G5,CPA2,CELA3A,PLA2G12B,RYR2,ATP2A3,ATP2B4,CPB1,PLA2G12A,CA2 |
| Glycerophospholipid metabolism | CRLS1,PCYT2,LPIN1,PLA2G3,PLA2G2A,ETNK2,PLA2G4D,LYCAT,PLA2G6,CHKA |
| Vascular smooth muscle contraction | PLA2G12A,MAP2K2A,GNA12A,GNA11B,PTGIR,MAPK3,PRKACB,CALD1,PLA2G4F,CALM |
| Arachidonic acid metabolism | EPHX2,CYP4F2,PLB1,HPGDS,CYP2J6,PTGS2B,CYP4F22,GGT5,ALOX8,ALOX5B.2 |
| Fat digestion and absorption | SLC27A4,MOGAT2,PPAP2C,DGAT2,Cel,PLA2G12B,LIPF,AGPAT1,APOA4,GOT2 |
| alpha-Linolenic acid metabolism | FADS2,PLA2G5,ACAA1,PLA2G6,PLA2G2D,PLA2G12A,PLA2G2A,PLA2G12B,PLA2G4F,ACOX1 |
| Ether lipid metabolism | EPT1,PLA2G4F,PLA2G12A,GAL3ST1A,PLA2G6,PAFAH1B3,LPCAT2,CEPT1B,PLD4,PPAP2CB |
| Linoleic acid metabolism | CYP2J6,CYP2P6,PLA2G4AA,PLA2G12B,PLA2G2A,CYP3A25,PLA2G4D,DHRS13L1,CYP3A65,PLA2G2F |
Protein Function
PLA2G1B has several biochemical functions, for example, bile acid binding,calcium ion binding,calcium-dependent phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G1B itself. We selected most functions PLA2G1B had, and list some proteins which have the same functions with PLA2G1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phospholipase A2 activity | PLA2G16,PRDX6,PNPLA3,PLA2G12B,PLA2G2A,PLA2G2D,LCAT,ABHD3,OC90,PLA2G4AA |
| bile acid binding | AKR1C21,PYGL,FABP1,NR1H4,FABP6,FABP10A,AKR1C2,STARD5 |
| receptor binding | TAC3,MIF,CADM4,DRD1A,PLXNC1,SEMA4D,HSPA1A,CDH5,NPY,AMACR |
| calcium-dependent phospholipase A2 activity | PLA2G4F,PLA2G4A,PLA2G2A,PLA2G4B,PLA2G12A,PLA2G3,PLA2G5 |
| calcium ion binding | TNNC2,S100A10,CAPN3,THBD,DLA,COMP,PCDH1G1,NINL,EGFL6,RCV1 |
Interacting Protein
PLA2G1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G1B.
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References
- Karray, A; Ben Ali, Y; et al. Drastic changes in the tissue-specific expression of secreted phospholipases A2 in chicken pulmonary disease. BIOCHIMIE 94:451-460(2012).
- Karray, A; Zarai, Z; et al. Kinetic properties of pancreatic and intestinal sPLA2 from chicken and mammals using the monomolecular film technique. JOURNAL OF COLLOID AND INTERFACE SCIENCE 363:620-625(2011).
