Pla2g12b

  • Official Full Name

    phospholipase A2, group XIIB

  • Overview

    Mouse Group XIIB secretory phospholipase A2-like protein, also knownas Group XIII secretory phospholipase A2-like protein, GXIII sPLA2-like, sPLA2-GXIIB, GXIIB, PLA2G13 and Pla2g12b, is a secreted protein which belongs to the phospholipase A2 family. Pla2g12b / PLA2G13 is strong expression in liver, small intestine and kidney. Mammalian secretory phospholipase A2s ( sPLA2s ) form a family of structurally related enzymes that are involved in a variety of physiological and pathological processes via the release of arachidonic acid from membrane phospholipids or the binding to specific membrane receptors. Phospholipases A2 / PLA2 are enzymes that release fatty acids from the second carbon group of glycerol. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids.

  • Synonyms

    GXIIB;FKSG71;PLA2G13;GXIIIsPLA2
Cat.# Product name Source (Host) Species Tag Protein Length Price
Pla2g12b-1192M Recombinant Mouse Pla2g12b protein, His-tagged HEK293 Mouse His 1-195 a.a.
PLA2G12B-12601Z Recombinant Zebrafish PLA2G12B Mammalian Cell Zebrafish His
PLA2G12B-1866MCL Recombinant Mouse PLA2G12B cell lysate Human Cell Mouse Non
PLA2G12B-1880H Recombinant Human PLA2G12B Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
Pla2g12b-4896M Recombinant Mouse Pla2g12b Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    Pla2g12b involved in several pathways and played different roles in them. We selected most pathways Pla2g12b participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pla2g12b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway ANGPT2,FGF12,LAT,BCL2L1,ARF6,IGF1,CALM4,FIGF,FGF18,PDGFRA
    alpha-Linolenic acid metabolism PLA2G3,PLA2G10,PLA2G2E,PLA2G4D,PLA2G5,PLA2G2A,FADS2,ACOX1,PLA2G4F,PLA2G1B
    Ether lipid metabolism PLD1,PLA2G4AA,GAL3ST1,PLD4,ENPP2,AGPS,PAFAH2,EPT1,PLD1A,CHPT1
    Linoleic acid metabolism PLA2G4AA,PLA2G4A,CYP3A25,PLA2G12A,CYP3A41B,CYP2C19,PLA2G6,CYP2P10,CYP2C9,CYP2C50
    Vascular smooth muscle contraction MYL6,BRAF,PRKACBB,KCNMB2,CALML3,MAP2K2A,ADCY1A,PRKG1A,CALM1A,GNA11A
    Pancreatic secretion CPA1,RAB11A,Car2,CTRL,PLCB2,ATP1A1,CLCA2,PNLIPRP2,ATP2A2,ATP2A1
    Fat digestion and absorption PLA2G2F,GOT2,MTTP,APOA1,PLA2G5,PLA2G10,PNLIP,PLA2G2D,CD36,DGAT2
    Metabolic pathways PGS1,AOX4,ybaS,ATP6V1E1B,ATP5I,AKR1B8,CYP3A65,PLA2G2A,UGT1A9,CYP2P10
    Glycerophospholipid metabolism MBOAT2B,PLD4,PNPLA6,GPCPD1,LPGAT1,AGPAT6,PCYT2,CDS2,PLA2G10,GPD1

    Protein Function

    Pla2g12b has several biochemical functions, for example, calcium ion binding,metal ion binding,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by Pla2g12b itself. We selected most functions Pla2g12b had, and list some proteins which have the same functions with Pla2g12b. You can find most of the proteins on our site.

    Function Related Protein
    phospholipase A2 activity PLA2G2E,PLA2G2A,OC90,PLA2G4A,ABHD3,LCAT,PLA2G6,PLA2G2F,PLB1,PLA2G1B
    molecular_function CRYGMXL2,CPNE5,SPP2,TMEM14CB,TMEM51,GM14430,ATXN7L2B,GRAMD2,TMED1B,EML6
    metal ion binding ECEL1,ZBTB7A,ZNF496,PPP4CB,ATP2C1,IRF2BP2,ZC4H2,COL3A1,ARSB,ZNF239
    calcium ion binding CD93,SPATA21,PPP3CA,TPM4,PVALB,S100A7,CALU,CABP2,CAPN1,LPCAT2

    Interacting Protein

    Pla2g12b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pla2g12b here. Most of them are supplied by our site. Hope this information will be useful for your research of Pla2g12b.

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