PKP2
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Official Full Name
plakophilin 2 -
Overview
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008] -
Synonyms
PKP2;plakophilin 2;ARVD9;plakophilin-2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PKP2-669H | Recombinant Human PKP2 Protein, His-tagged | E.coli | Human | His | Asp571~Ala849 | |
| PKP2-35H | Recombinant Human PKP2 Protein, His-tagged | E.coli | Human | His | ||
| PKP2-6287Z | Recombinant Zebrafish PKP2 | Mammalian Cells | Zebrafish | His |
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| PKP2-3147HCL | Recombinant Human PKP2 293 Cell Lysate | HEK293 | Human | Non |
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| PKP2-4920H | Recombinant Human PKP2 Protein (Asp571-Ala849), His tagged | E.coli | Human | His | Asp571-Ala849 |
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| PKP2-670H | Recombinant Human PKP2 Protein, C-MYC/DDK tagged | HEK293 | Human | Myc&DDK |
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Involved Pathway
PKP2 involved in several pathways and played different roles in them. We selected most pathways PKP2 participated on our site, such as Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with PKP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | CACNG2,SGCD,CACNA2D1,ITGB5,DES,CACNB1,GJA1,LEF1,CACNG6,CACNG7 |
Protein Function
PKP2 has several biochemical functions, for example, alpha-catenin binding,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication,intermediate filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKP2 itself. We selected most functions PKP2 had, and list some proteins which have the same functions with PKP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SDHA,CYFIP2,ACAT2,C21orf119,RPL28,NETO2,STOX1,HTR1E,NOX5,ARHGEF3 |
| molecular_function | SH2D5,SCRN1,GSDMC3,TMEM57A,CPNE2,TCHP,TMEM150A,SCGB2A2,LMAN2LB,MSTO1 |
| protein complex scaffold | MAP2K2,AXIN1,MPP7,AKAP6,ARRB2,SLC9A1,WWC3,AKAP1,DISC1,AKAP9 |
| protein kinase C binding | C1QBP,GNB2L1,PKN1,TOP2A,TRPV4,PARD3,SDPRA,ADD3,LDB3,PRKCSH |
| alpha-catenin binding | PKP3,NUMB,AJUBA,CDH2,JUPA,JUB,JUP,CDH24,VCL,CTNNB1 |
| ion channel binding | PACS1,CAMK2D,SLC8A1,KCND3,FGF13,KCNE2,CAV1,USP10,PDE4D,ACTN2 |
| sodium channel regulator activity | TMPRSS3,YWHAH,FXYD4,FXYD1,SGK3,FXYD3,SGK2A,FGF12,FXYD7,FXYD5 |
| cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication | JUP,CTNNA3,DSC2,DSG2,DSP |
| intermediate filament binding | NES,PKP1,SYNM,EVPLA,MTM1,EVPL,NME2 |
Interacting Protein
PKP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKP2.
MTUS2;NDEL1;DSP;MARK3;FOS;KRT14;KRT18;KRT8;VIM;KRT5;SFN;TRMT10C
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References
- Rickelt, S; et al. Plakophilin-2: a cell-cell adhesion plaque molecule of selective and fundamental importance in cardiac functions and tumor cell growth. CELL AND TISSUE RESEARCH 348:281-294(2012).
- Rickelt, S; Rizzo, S; et al. A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata. MODERN PATHOLOGY 23:1429-1437(2010).
