PKD2L1
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Official Full Name
polycystic kidney disease 2-like 1 -
Overview
This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane;domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in;cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two;transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PKD2L1;polycystic kidney disease 2-like 1;PKD2L, PKDL;polycystic kidney disease 2-like 1 protein;PCL;transient receptor potential cation channel;subfamily P;member 3;TRPP3;B830002B15;BC046386;PK2L1;PK2L1_HUMAN;PKD2L;PKDL;Polycystic kidney disease 2 like 1 protein;Polycystin L;Polycystin-2 homolog;Polycystin-2L1;Polycystin-L;Polycystin-L1;transient receptor potential cation channel, subfamily P, member 3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PKD2L1-1739H | Recombinant Human PKD2L1, GST-tagged | E.coli | Human | GST | C-term-245aa | |
| PKD2L1-12861M | Recombinant Mouse PKD2L1 Protein | Mammalian Cells | Mouse | His |
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| PKD2L1-1185HFL | Recombinant Human PKD2L1 protein, His&Flag-tagged | HEK293 | Human | His&Flag | 1-758 aa |
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| PKD2L1-6780M | Recombinant Mouse PKD2L1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PKD2L1-6780M-B | Recombinant Mouse PKD2L1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PKD2L1 involved in several pathways and played different roles in them. We selected most pathways PKD2L1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PKD2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PKD2L1 has several biochemical functions, for example, alpha-actinin binding,calcium activated cation channel activity,calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PKD2L1 itself. We selected most functions PKD2L1 had, and list some proteins which have the same functions with PKD2L1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cation channel activity | TRPV2,P2RX1,TRPC1,PKD1,TRPM1B,TRPM1A,GRIN2A,ACCN3,ASIC1A,FAM26E |
| calcium activated cation channel activity | TRPM5,CATSPER1,CATSPER2,TRPM4,TRPM4C,ANO10,ANO6,TRPM4A,CALHM1,TMEM63C |
| cytoskeletal protein binding | EZRB,FARP1,EPB41L5,PTPN4A,FRMD5,EPB41L3B,ANXA2,PDLIM3,CAPN2,NCKIPSD |
| sodium channel activity | SCN4AB,SCN12AA,KCNK1,SLC4A11,TRPM5,ASIC1A,ASIC4A,ASIC1C,SCN1LAB,SCN8AB |
| calcium channel activity | TRPM2,CACNA1SA,CACNA1SB,CUL5,TRPC1,TRPC3,CACNA1DA,TRPC6A,TRPN1,RYR1B |
| calcium ion binding | CDH6,PCDH15,CASQ1A,UMOD,CASQ1,HEG,NCL,SLC24A4A,CASQ1B,TPT1 |
| alpha-actinin binding | RARA,ALMS1,PPARG,KCNN2,DAG1,ADORA2A,MYOT,XIRP2,MAGI1,KCNA5 |
| calcium-activated potassium channel activity | KCNMA1,KCNK18,KCNMB2,KCNN4,MTMR6,HPN,KCNN2,KCNT1,CCT8L2,KCNMA1A |
| contributes_to cation transmembrane transporter activity | PKD1L3 |
Interacting Protein
PKD2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKD2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKD2L1.
PKD1L3
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