PITPNM3
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Official Full Name
PITPNM family member 3 -
Overview
This gene encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. The calcium-binding protein has phosphatidylinositol (PI) transfer activity and interacts with the protein tyrosine kinase PTK2B (also known as PYK2). The protein is homologous to a Drosophila protein that is implicated in the visual transduction pathway in flies. Mutations in this gene result in autosomal dominant cone dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PITPNM3;PITPNM family member 3;membrane-associated phosphatidylinositol transfer protein 3;NIR1;RDGBA3;CORD5;Membrane associated phosphatidylinositol transfer protein 3;MGC157740;MGC157741;NIR 1;Phosphatidylinositol transfer protein, membrane-associated 3;PITPnm 3;PITPNM;PYK2 N terminal domain interacting receptor 1;PYK2 N-terminal domain-interacting receptor 1;retinal degeneration B alpha 3;NIR-1
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- GST
- His
- Myc&DDK
- His&Myc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PITPNM3-1735H | Recombinant Human PITPNM3, GST-tagged | E.coli | Human | GST | 472-544aa | |
| PITPNM3-12847M | Recombinant Mouse PITPNM3 Protein | Mammalian Cells | Mouse | His |
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| PITPNM3-12H | Recombinant Human PITPNM3 protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| PITPNM3-4790H | Recombinant Human PITPNM3 protein, His&Myc-tagged | E.coli | Human | His&Myc | 387-597aa |
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| Pitpnm3-4882M | Recombinant Mouse Pitpnm3 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| PITPNM3-5847H | Recombinant Human PITPNM3 protein, His&Myc-tagged | Insect Cells | Human | His&Myc | 387-597aa |
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| PITPNM3-6484H | Recombinant Human PITPNM3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| PITPNM3-6767M | Recombinant Mouse PITPNM3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PITPNM3-6767M-B | Recombinant Mouse PITPNM3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PITPNM3 involved in several pathways and played different roles in them. We selected most pathways PITPNM3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PITPNM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PITPNM3 has several biochemical functions, for example, calcium ion binding,lipid binding,phosphatidylinositol transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PITPNM3 itself. We selected most functions PITPNM3 had, and list some proteins which have the same functions with PITPNM3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | ACTN3A,CALM1,PCDH2AB12,Npnt,CABP1A,CAPNS1A,NID1,MYLZ3,PCDHB12,CRB2B |
| lipid binding | GLTP,BPIFA5,RBP7B,ATP5G1,FABP7B,UNC119,LPAR4,PCYT1A,PITPNM2,PLTP |
| phosphatidylinositol transporter activity | PITPNA,PITPNM1,PITPNBL,TNFAIP8L3,SCP2,PITPNC1 |
| protein binding | ZNF286A,UBE2H,GEMIN6,SYT6,MAPK15,CD99L2,RBBP8,DNAI1,AICDA,CYLD |
| receptor tyrosine kinase binding | ANGPT1,GAS6,TP53,LRP4,ZNF259,PLCG1,SHC3,NRG3,PCNA,DNAJA3 |
Interacting Protein
PITPNM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PITPNM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PITPNM3.
CCL18;q7chg5_yerpe;ligA;VAPA
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References
- Meng, FB; Li, W; et al. CCL18 promotes epithelial-mesenchymal transition, invasion and migration of pancreatic cancer cells in pancreatic ductal adenocarcinoma. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1109-1120(2015).
- He, CH; Su, SC; et al. Overexpression of PITPNM3 promotes hepatocellular carcinoma cell metastasis. CHINESE SCIENCE BULLETIN 59:1326-1333(2014).
