PITPNA
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Official Full Name
phosphatidylinositol transfer protein, alpha -
Overview
This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase. -
Synonyms
PITPNA;phosphatidylinositol transfer protein, alpha;phosphotidylinositol transfer protein , PITPN;phosphatidylinositol transfer protein alpha isoform;VIB1A;MGC99649;Phosphatidylinositol transfer protein alpha;Phosphotidylinositol transfer protein;PITP alpha;PITPNB;PtdIns transfer protein alpha;PtdInsTP;PI-TP-alpha;ptdInsTP alpha;PITPN;PI-TPalpha
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Rat
- Mammalian Cells
- E.coli
- HEK293
- Human Cells
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
PITPNA involved in several pathways and played different roles in them. We selected most pathways PITPNA participated on our site, such as Axon guidance,Developmental Biology,EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PITPNA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | SIAH2,RHOGA,CLTA,RHOB,MED18,IL17RD,MYL12A,LGI1A,CNTN1,NR5A1 |
| Netrin-1 signaling | RGMB,TRPC4,RGMA,UNC5D,SIAH2,RNF8,NTN1A,NTN1B,TRPC5,HFE2 |
| Axon guidance | SHB,DUSP7,RGS3,SEMA3AA,NETO2,CSF2RA,DCC,FRS2,SPRED1,EPHB1 |
| EGFR1 Signaling Pathway | JUND,EEF1A1,RGS16,WNK1,TNK2,AP2A1,STXBP1A,GRB10,RGS5B,CEBPB |
| Role of second messengers in netrin-1 signaling | TRPC4,TRPC5 |
Protein Function
PITPNA has several biochemical functions, for example, lipid binding,phosphatidylcholine transporter activity,phosphatidylinositol transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PITPNA itself. We selected most functions PITPNA had, and list some proteins which have the same functions with PITPNA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylcholine transporter activity | PCTP,ABCB4,PITPNBL |
| phosphatidylinositol transporter activity | PITPNM3,PITPNM1,TNFAIP8L3,SCP2,PITPNBL,PITPNC1 |
| lipid binding | AP2A2,FAM123B,FAM123A,BPIFB6,BAX,OSBPL9,S100A13,HDLBP,PITPNC1,ACOT11A |
Interacting Protein
PITPNA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PITPNA here. Most of them are supplied by our site. Hope this information will be useful for your research of PITPNA.
GTF2F2;MORF4L2;PMVK;HSDL1;MLKL;SIRT3;CSNK2B;pi3p;PLK1;Dync1li1;Cdc26
Resources
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References
- Dovas, A; Choi, Y; et al. Serine 34 Phosphorylation of Rho Guanine Dissociation Inhibitor (RhoGDI alpha) Links Signaling from Conventional Protein Kinase C to RhoGTPase in Cell Adhesion. JOURNAL OF BIOLOGICAL CHEMISTRY 285:23294-23306(2010).
- Speak, AO; Cerundolo, V; et al. CD1d presentation of glycolipids. IMMUNOLOGY AND CELL BIOLOGY 86:588-597(2008).
