PIR
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Official Full Name
pirin (iron-binding nuclear protein) -
Overview
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. -
Synonyms
PIR;pirin (iron-binding nuclear protein);pirin;Iron binding nuclear protein;OTTHUMP00000022961;OTTHUMP00000022962;probable quercetinase;probable quercetin 2,3-dioxygenase PIR
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PIR involved in several pathways and played different roles in them. We selected most pathways PIR participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PIR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PIR has several biochemical functions, for example, metal ion binding,protein binding,quercetin 2,3-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIR itself. We selected most functions PIR had, and list some proteins which have the same functions with PIR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription cofactor activity | MED17,LDB2A,POU2AF1,NMI,ZMYND11,THRAP3,AIRE,FAM48A,SLC26A3,LDB1B |
| metal ion binding | CYP51,KLF2B,ZNF207B,TRIM35-34,TSHZ1,MGRN1B,ZNF500,LATS2,SMYD1,PVALB8 |
| protein binding | CLDN2,STXBP3,CADPS,AHCY,ZC3H18,SIT1,KDM2B,DTX1,RND3,KRT25 |
Interacting Protein
PIR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIR here. Most of them are supplied by our site. Hope this information will be useful for your research of PIR.
BCL3;SMAD9
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References
- Zhong, HH; Fazenbaker, C; et al. MEDI-573, Alone or in Combination with Mammalian Target of Rapamycin Inhibitors, Targets the Insulin-like Growth Factor Pathway in Sarcomas. MOLECULAR CANCER THERAPEUTICS 13:2662-2673(2014).
- Moon, HY; Van, TL; et al. Cell-Surface Expression of Aspergillus saitoi-Derived Functional alpha-1,2-Mannosidase on Yarrowia lipolytica for Glycan Remodeling. JOURNAL OF MICROBIOLOGY 51:506-514(2013).
